ArticleJournal of experimental zoology. Part B, Molecular and developmental evolution2011
Developmental and genetic origins of murine long bone length variation.
Article in Journal of experimental zoology. Part B, Molecular and developmental evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Microevolutionary divergence and plasticity of laryngeal shape in the house mouse (American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Developmental trajectories in laryngeal anatomy of California mice (Royal Society open science · 2025Article
- BMP3 Affects Cortical and Trabecular Long Bone Development in Mice.International journal of molecular sciences · 2022Article
- Early Life Exposure to a Diet With a Supramolecular Lipid Structure Close to That of Mammalian Milk Improves Early Life Growth, Skeletal Development, and Later Life Neurocognitive Function in Individually and Socially Housed Male C57BL/6J Mice.Frontiers in neuroscience · 2022Article
- Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Long bone histomorphogenesis of the naked mole-rat: Histodiversity and intraspecific variation.Journal of anatomy · 2021Article
- A New Pipeline to Automatically Segment and Semi-Automatically Measure Bone Length on 3D Models Obtained by Computed Tomography.Frontiers in cell and developmental biology · 2021Article
- A NaFrontiers in cell and developmental biology · 2021Article
- RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.Osteoarthritis and cartilage · 2020Article
- Individual housing of male C57BL/6J mice after weaning impairs growth and predisposes for obesity.PloS one · 2020Article
- Evidence for Genetic Contribution to Variation in Posttraumatic Osteoarthritis in Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Review
- Genetic Dissection of a Supergene ImplicatesGenetics · 2018Article
- Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Article
- Isometric Scaling in Developing Long Bones Is Achieved by an Optimal Epiphyseal Growth Balance.PLoS biology · 2015Article
- Article
- Mapping the natural variation in whole bone stiffness and strength across skeletal sites.Bone · 2014Article
- Two developmentally temporal quantitative trait loci underlie convergent evolution of increased branchial bone length in sticklebacks.Proceedings. Biological sciences · 2014Article
- Genomic correlates of relationship QTL involved in fore- versus hind limb divergence in mice.Genome biology and evolution · 2013Article
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7 authors.
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Abstract
If we wish to understand whether development influences the rate or direction of morphological evolution, we must first understand the developmental bases of morphological variation within species. However, quantitative variation in adult morphology is the product of molecular and cellular processes unfolding from embryonic development through juvenile growth to maturity. The Atchley-Hall model provides a useful framework for dissecting complex morphologies into their component parts as a way of determining which developmental processes contribute to variation in adult form. We have examined differences in postnatal allometry and the patterns of genetic correlation between age-specific traits for ten recombinant inbred strains of mice generated from an intercross of LG/J and SM/J. Long bone length is closely tied to body size, but variation in adult morphology is more closely tied to differences in growth rate between 3 and 5 weeks of age. These analyses show that variation generated during early development is overridden by variation generated later in life. To more precisely determine the cellular processes generating this variation we then examined the cellular dynamics of long bone growth plates at the time of maximum elongation rate differences in the parent strains. Our analyses revealed that variation in long bone length is the result of faster elongation rates of the LG/J stain. The developmental bases for these differences in growth rate involve the rate of cell division and chondrocyte hypertrophy in the growth plate.
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