ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2011
The proportional lack of archaeal pathogens: Do viruses/phages hold the key?
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Computational identification of antigen-specific T cell groups through generative epitope modeling.iScience · 2026Article
- The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?Pathogens (Basel, Switzerland) · 2025Review
- Archaea in the Human Microbiome and Potential Effects on Human Infectious Disease.Emerging infectious diseases · 2024Review
- Translating phage therapy into the clinic: Recent accomplishments but continuing challenges.PLoS biology · 2023Article
- Mining of Thousands of Prokaryotic Genomes Reveals High Abundance of Prophages with a Strictly Narrow Host Range.mSystems · 2022Article
- Accessible and Insightful Scientific Learning Experiences Using the Microorganism Haloferax volcanii.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Scope of Archaea in Fish Feed: a New Chapter in Aquafeed Probiotics?Probiotics and antimicrobial proteins · 2021Review
- The host-associated archaeome.Nature reviews. Microbiology · 2020Review
- Evolution of Genomic Base Composition: From Single Cell Microbes to Multicellular Animals.Computational and structural biotechnology journal · 2019Review
- Article
- Do Viruses Exchange Genes across Superkingdoms of Life?Frontiers in microbiology · 2017Article
- From chemical metabolism to life: the origin of the genetic coding process.Beilstein journal of organic chemistry · 2017Review
- Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children.Frontiers in microbiology · 2017Article
- Forbidden phenotypes and the limits of evolution.Interface focus · 2015Review
- Archaea in and on the Human Body: Health Implications and Future Directions.PLoS pathogens · 2015Review
- Multiorganismal insects: diversity and function of resident microorganisms.Annual review of entomology · 2015Review
- Gut inflammation and immunity: what is the role of the human gut virome?Mediators of inflammation · 2015Review
- Review
- Symbiosis as a general principle in eukaryotic evolution.Cold Spring Harbor perspectives in biology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Archaea inhabit the human body and possess some characteristics of pathogens, there is a notable lack of pathogenic archaeal species identified to date. We hypothesize that the scarcity of disease-causing Archaea is due, in part, to mutually-exclusive phage and virus populations infecting Bacteria and Archaea, coupled with an association of bacterial virulence factors with phages or mobile elements. The ability of bacterial phages to infect Bacteria and then use them as a vehicle to infect eukaryotes may be difficult for archaeal viruses to evolve independently. Differences in extracellular structures between Bacteria and Archaea would make adsorption of bacterial phage particles onto Archaea (i.e. horizontal transfer of virulence) exceedingly hard. If phage and virus populations are indeed exclusive to their respective host Domains, this has important implications for both the evolution of pathogens and approaches to infectious disease control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.