Evidence map›Paper›PMID 21328090›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2011

Clinical correlates of health-related quality of life among opioid-dependent patients.

Kevin C Heslin, Judith A Stein, Keith G Heinzerling, Deyu Pan, Christine Magladry, Ron D Hays

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. French-Canadian Translation and Cultural Adaptation of the Clinical Opiate Withdrawal Scale: The COWS-FC.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022
    Article
  3. Article
  4. The role of dual diagnosis in health-related quality of life among treatment-seeking patients in Spain.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Article
  5. Article
  6. Quality of life and health of opioid-dependent subjects in India.Journal of neurosciences in rural practice · 2014
    Article
  7. Article
  8. Functional status, life-space mobility, and quality of life: a longitudinal mediation analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin C Heslinkevin.heslin@va.gov
Judith A Stein
Keith G Heinzerling
Deyu Pan
Christine Magladry
Ron D Hays

Funding

The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI MILBURN, NORWEETA GERMAINE, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
NEW MODELS &METHODS FOR SUBSTANCE ABUSE RESEARCHP01DA001070 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTLER, PETER M · 1985 to 2012
$14.6M
Pharmacogenomics and Medication Development for Methamphetamine DependenceK23DA023558 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HEINZERLING, KEITH GREGORY · 2008 to 2012
$848k
Racial/ethnic Disparities in Mental Healthcare Use by Substance Abuse ClientsR03DA018762 · NIDA · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI HESLIN, KEVIN C · 2007 to 2008
$125k
NIA NIH HHS P30 AG021684NIA NIH HHS P30AG021684NIDA NIH HHS 1 K23 DA 023558NIDA NIH HHS 1P01-DA-01070-37NIDA NIH HHS 1R03-DA018762-01A2NIDA NIH HHS K23 DA023558NIDA NIH HHS P01 DA001070NIDA NIH HHS R03 DA018762NIMHD NIH HHS 2P20MD000182NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

purposePrevious work suggests that opioid users have lower health-related quality of life (HRQOL) than patients with more prevalent chronic illnesses such as hypertension or diabetes. Although comparisons with population norms are informative, studies of the correlates of HRQOL for opioid users are needed to plan clinical services.

methodsWe tested a conceptual model of the pathways between physiologic factors and symptoms in relation to HRQOL among 344 opioid users in a clinical trial. Physical and mental HRQOL were measured by the Short-Form (SF)-36; withdrawal signs, symptoms, and functioning were also measured with validated instruments. Using structural equation modeling, we tested hypotheses that medical history directly predicts withdrawal signs and symptoms, and that medical history, withdrawal signs and symptoms, and functioning predict the physical and mental HRQOL latent variables of the SF-36.

resultsMost hypothesized relationships were significant, and model fit was good. The model explained 36% of the variance in mental HRQOL and 34% of the variance in physical HRQOL.

conclusionsThe conceptual framework appears valid for explaining variation in the physical and mental HRQOL of opioid users undergoing medically managed withdrawal. Analysis of longitudinal data would help to evaluate more rigorously the adequacy of the model for explaining HRQOL in opioid withdrawal.

Indexed as

Quality of LifeAdolescentAdultAnalgesics, OpioidBody Mass IndexBuprenorphineHumansMiddle AgedNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersSeverity of Illness IndexSickness Impact ProfileSubstance Withdrawal SyndromeYoung AdultAnalgesics, OpioidBuprenorphineNarcotic Antagonists

Identifiers

PMID21328090
PMCPMC3178032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.