ArticleParasitology research2011
Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice.
Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 90 citations in OpenAlex.
- The antifibrotic effect of Vildagliptin and Diaminodiphenyl Sulfone in murine schistosomiasis mansoni.Scientific reports · 2025Article
- Zingiber officinale Ameliorates Acute Toxoplasmosis-Induced Pathology in Mice.Acta parasitologica · 2024Article
- Therapeutic potential of natural products in schistosomiasis-associated liver fibrosis.Frontiers in pharmacology · 2024Review
- Computer-Aided Discovery ofBiomedical engineering and computational biology · 2024Article
- Article
- Assessment of therapeutic potential ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Article
- Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs.Molecules (Basel, Switzerland) · 2021Review
- Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment.PLoS neglected tropical diseases · 2021Article
- Article
- Antiparasitic effects of ethanolic extracts ofParasitology · 2020Article
- In vitro Effects ofResearch and reports in tropical medicine · 2020Article
- Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.International journal for parasitology. Drugs and drug resistance · 2019Article
- Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects againstInfection and drug resistance · 2019Article
- Efficacy of Sida pilosa Retz aqueous extract against Schistosoma mansoni - induced granulomatous inflammation in the liver and the intestine of mice: histomorphometry and gastrointestinal motility evaluation.BMC complementary and alternative medicine · 2018Article
- Antischistosomal Properties of Hederacolchiside A1 Isolated fromMolecules (Basel, Switzerland) · 2018Article
- The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.Molecules (Basel, Switzerland) · 2016Review
- Article
- Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni.PLoS neglected tropical diseases · 2015Article
- Ginger from ancient times to the new outlook.Jundishapur journal of natural pharmaceutical products · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repeated chemotherapy of schistosomiasis has resulted in the emergence of drug-resistant schistosome strains. The development of such resistance has drawn the attention of many authors to alternative drugs. Many medicinal plants were studied to investigate their antischistosomal potency. The present work aimed to evaluate antischistosomal activity of crude aqueous extract of ginger against Schistosoma mansoni. Sixteen mice of C57 strain were exposed to 100 ± 10 cercariae per mouse by the tail immersion method; the mice were divided into two groups: untreated group and ginger-treated one. All mice were sacrificed at the end of 10th week post-infection. Worm recovery and egg counting in the hepatic tissues and faeces were determined. Surface topography of the recovered worms was studied by scanning electron microscopy. Histopathological examination of liver and intestine was done using routine histological procedures. The worm burden and the egg density in liver and faeces of mice treated with ginger were fewer than in non-treated ones. Scanning electron microscopical examination revealed that male worms recovered from mice treated with ginger lost their normal surface architecture, since its surface showed partial loss of tubercles' spines, extensive erosion in inter-tubercle tegumental regions and numerous small blebs around tubercles. Histopathological data indicated a reduction in the number and size of granulomatous inflammatory infiltrations in the liver and intestine of treated mice compared to non-treated mice. The results of the present work suggested that ginger has antischistosomal activities and provided a basis for subsequent experimental and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.