ArticleMolecular biology reports2011
Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Tailoring human joint-on-a-chip: from biological principles, materials, to disease modeling.Materials today. Bio · 2026Review
- Unraveling Osteoarthritis: Mechanistic Insights and Emerging Therapies Targeting Pain and Inflammation.Biomolecules · 2025Review
- Article
- Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (International journal of molecular sciences · 2022Article
- The Added Value of the "Co" in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development.Frontiers in bioengineering and biotechnology · 2022Review
- TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons.Scientific reports · 2021Article
- L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium in an experimentally-induced knee osteoarthritis rat model.Iranian journal of basic medical sciences · 2020Article
- Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.The Clinical journal of pain · 2020Article
- The Pharmacology of Pain Associated With the Monoiodoacetate Model of Osteoarthritis.Frontiers in pharmacology · 2019Review
- Down-regulation of microRNA-23b aggravates LPS-induced inflammatory injury in chondrogenic ATDC5 cells by targeting PDCD4.Iranian journal of basic medical sciences · 2018Article
- Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Characterization of degenerative human facet joints and facet joint capsular tissues.Osteoarthritis and cartilage · 2015Article
- Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.Arthritis research & therapy · 2014Article
- Article
- Review
- Osteoarthritis pain mechanisms: basic studies in animal models.Osteoarthritis and cartilage · 2013Review
- Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction.Neuroscience · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Osteoarthritis (OA) is an age-related degenerative disease of cartilaginous tissues that is accompanied by hyperalgesia. Molecular cause and effect relationships between OA and pain remain to be elucidated. In this study, we have developed an experimental ex vivo organ co-culture system with dorsal root ganglia (DRGs) and knee synovial tissues from OA patients or unaffected human subjects. Our results suggest that tissues may generate symptomatic pain by altering the functional properties of sensory neurons. Specifically, we find that the expression levels of genes associated with neuronal pathways (e.g., SP, NK1, NK2, NPYR1, NPYR2, α2δ1) or inflammation (COX2/PTGS2 and IL6/interferon β2) are clearly elevated in DRG explants cultured in the presence of OA derived synovial tissues. These findings are consistent with a model in which cytokines and pain molecules produced by knee synovium sensitize nociceptive neurons in tissues peripheral to joint cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.