ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2011
Bisphosphonate-induced osteonecrosis of the external ear canal: a retrospective study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 35 citations in OpenAlex.
- Benign Osteonecrosis of the External Auditory Canal: Diagnostic Challenges and Outcomes in a Case Series.Cureus · 2026Article
- Article
- Bilateral osteonecrosis of the external auditory canal caused by bone-modifying agents for cancer bone metastases.International cancer conference journal · 2025Article
- Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal.BMJ case reports · 2021Article
- Infection as an Important Factor in Medication-Related Osteonecrosis of the Jaw (MRONJ).Medicina (Kaunas, Lithuania) · 2021Review
- Long-Term Oral Bisphosphonate Therapy and Fractures in Older Women: The Women's Health Initiative.Journal of the American Geriatrics Society · 2017Article
- Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma.Journal of veterinary internal medicine · 2016Article
- Bisphosphonate Related Osteonecrosis of the Jaw: An Update.Journal of maxillofacial and oral surgery · 2014Review
- External auditory canal and middle ear cholesteatoma and osteonecrosis in bisphosphonate-treated osteoporosis patients: a Danish national register-based cohort study and literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- [Bilateral bisphosphonate-associated osteonecrosis of the external ear canal : a rare case].HNO · 2012Article
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7 authors at 1 institution in 1 country.
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Abstract
In 2003, osteonecrosis of the jaw was described as an intraoral complication of bisphosphonate therapy. More recently, cases of avascular necrosis of the hip were reported in patients with long-lasting bisphosphonate therapy. Thus, it was the aim of the present study to analyze cases of benign osteonecrosis of the external ear canal and to retrospectively identify a possible relationship to long-lasting bisphosphonate therapy. 13 patients with osteonecrosis of the external ear canal operated on between 2005 and 2009 were included. Patient histories were reviewed for possible previous or current bisphosphonate therapy. Three patients with osteonecrosis of the external ear canal and long-term bisphosphonate therapy could be identified. They had been treated either for breast cancer or multiple myeloma. Certainly, the jaw is an area of increased risk for developing osteonecrosis with its high mechanical stress and intraoral bacterial flora. However, osteonecrosis of the hips and the external ear canal in patients receiving long-term bisphosphonate therapy necessitate further investigation of a possible systemic, bisphosphonate-related phenomenon.
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