ArticleArchives of environmental contamination and toxicology2011
δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 and peptide transporter 2*2 haplotype may differentially mediate lead exposure in male children.
Article in Archives of environmental contamination and toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.Environmental science and pollution research international · 2022Pooled it
- Article
- Delta-Aminolevulinic Acid Dehydratase, Low Blood Lead Levels, Social Factors, and Intellectual Function in an Afro-Brazilian Children Community.Biological trace element research · 2022Article
- Schiff Base Derived from 4,4'-methylenedianiline and p-anisaldehyde: Colorimetric Sensor for CuJournal of fluorescence · 2019Article
- Colorimetric Determination of PbJournal of fluorescence · 2017Article
- Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study.Biochemical pharmacology · 2017Article
- Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice.Journal of applied toxicology : JAT · 2015Article
- Early life lead exposure causes gender-specific changes in the DNA methylation profile of DNA extracted from dried blood spots.Epigenomics · 2015Article
- ALAD genotypes and blood lead levels of neonates and children from e-waste exposure in Guiyu, China.Environmental science and pollution research international · 2014Article
- Early chronic low-level lead exposure produces glomerular hypertrophy in young C57BL/6J mice.Toxicology letters · 2014Article
- Microglial disruption in young mice with early chronic lead exposure.Toxicology letters · 2013Article
- Improved genotyping of N-acetyltransferase 2: role of the ultra-slow acetylators.EXCLI journal · 2013Article
- δ-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Child low-level lead (Pb) exposure is an unresolved public health problem and an unaddressed child health disparity. Particularly in cases of low-level exposure, source removal can be impossible to accomplish, and the only practical strategy for reducing risk may be primary prevention. Genetic biomarkers of increased neurotoxic risk could help to identify small subgroups of children for early intervention. Previous studies have suggested that, by way of a distinct mechanism, δ-aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD(2)) and/or peptide transporter 2*2 haplotype (hPEPT2*2) increase Pb blood burden in children. Studies have not yet examined whether sex mediates the effects of genotype on blood Pb burden. Also, previous studies have not included blood iron (Fe) level in their analyses. Blood and cheek cell samples were obtained from 306 minority children, ages 5.1 to 12.9 years. (208)Pb and (56)Fe levels were determined with inductively coupled plasma-mass spectrometry. General linear model analyses were used to examine differences in Pb blood burden by genotype and sex while controlling for blood Fe level. The sample geometric mean Pb level was 2.75 μg/dl. Pb blood burden was differentially higher in ALAD(2) heterozygous boys and hPEPT2*2 homozygous boys. These results suggest that the effect of ALAD(2) and hPEPT2*2 on Pb blood burden may be sexually dimorphic. ALAD(2) and hPEPT2*2 may be novel biomarkers of health and mental health risks in male children exposed to low levels of Pb.
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