ArticleEuropean journal of nuclear medicine and molecular imaging2011
Relationship between infarct size and severity measured by gated SPECT and long-term left ventricular remodelling after acute myocardial infarction.
Article in European journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial.European journal of nuclear medicine and molecular imaging · 2016Trial
- Assessment of Left Ventricular Shape Index and Eccentricity Index as Promising Parameters for Detection of Left Ventricular Remodeling in Cardiovascular Events.Current cardiology reviews · 2025Review
- Left Ventricular Adverse Remodeling in Ischemic Heart Disease: Emerging Cardiac Magnetic Resonance Imaging Biomarkers.Journal of clinical medicine · 2023Review
- Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease.Clinical physiology and functional imaging · 2022Article
- Myocardial Blood Flow and Flow Reserve in Patients With Acute Myocardial Infarction and Obstructive and Non-Obstructive Coronary Arteries: CZT SPECT Study.Frontiers in nuclear medicine · 2022Article
- Impact of tissue protrusion after coronary stenting in patients with ST-segment elevation myocardial infarction.The international journal of cardiovascular imaging · 2019Article
- Summed thickening score by myocardial perfusion imaging: A risk factor of left ventricular remodeling in patients with myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Impact of Remote Ischemic Postconditioning during Primary Percutaneous Coronary Intervention on Left Ventricular Remodeling after Anterior Wall ST-Segment Elevation Myocardial Infarction: A Single-Center Experience.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- Proprotein convertase subtilisin/kexin type 9 expression is transiently up-regulated in the acute period of myocardial infarction in rat.BMC cardiovascular disorders · 2014Article
- Reply to "letter to the editor: 'cyclosporin A in left ventricular remodeling after myocardial infarction'".American journal of physiology. Heart and circulatory physiology · 2014Article
- Cyclosporin A in left ventricular remodeling after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2014Article
- Prediction of left ventricular remodelling by radionuclide imaging.European journal of nuclear medicine and molecular imaging · 2011Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeAfter acute myocardial infarction (AMI), left ventricular (LV) remodelling may occur despite successful reperfusion. This study aimed to investigate by gated single photon emission computed tomography (SPECT) the long-term evolution of myocardial perfusion and LV function after AMI and to identify the predictors of LV remodelling.
methodsSixty-eight AMI patients successfully treated by primary percutaneous coronary intervention underwent (99m)Tc-sestamibi gated SPECT at 1 month (baseline) and over 6-month follow-up after the acute event. LV remodelling was defined as 20% increase in LV end-diastolic volume at follow-up.
resultsAt baseline, patients with remodelling (n = 14) showed larger (infarct size 29.3 ± 7.8%) and more transmural (infarct severity 0.28 ± 0.10) infarctions, and reduced LV ejection fraction (35.4 ± 5.6%), but similar LV volume indexes, compared to patients without remodelling (n = 54) (infarct size 20.8 ± 14.4%, p < 0.05, infarct severity 0.40 ± 0.11, p < 0.001, ejection fraction 44.5 ± 9.2, p < 0.001). At stepwise multivariate regression analysis, infarct severity showed the best predictive value for predicting LV remodelling (F = 5.54, p < 0.05). Using the thresholds identified by receiver-operating characteristic curve analysis, infarct size and severity detected patients with remodelling with 75% accuracy and 95% negative predictive value. Infarct resorption (defined as the defect size difference between follow-up and baseline) was comparable between patients with (-4.4 ± 8.4%) and without remodelling (-6.8 ± 9.4%) (p = NS).
conclusionPerfusion parameters assessed by gated SPECT in the subacute phase after successfully treated AMI correlate with changes in functional parameters at long-term follow-up. Infarct severity is more effective than infarct size, but both are helpful for predicting LV remodelling.
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