ReviewMetabolic brain disease2011
Neurological disorders associated with cassava diet: a review of putative etiological mechanisms.
Review in Metabolic brain disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 58 citations in OpenAlex.
- Cyanide overproduction impairs cellular bioenergetics in Down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- β-Glucosidase Activity ofFoods (Basel, Switzerland) · 2025Review
- Epidemics and outbreaks of peripheral nervous system disorders: II. Toxic and nutritional causes.Journal of neurology · 2021Article
- Preclinical and clinical research on the toxic and neurological effects of cassava (Manihot esculenta Crantz) consumption.Metabolic brain disease · 2020Review
- Chronic consumption of cassava juice induces cellular stress in rat substantia nigra.Iranian journal of basic medical sciences · 2020Article
- Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs.Annals of the New York Academy of Sciences · 2018Article
- Cassava, konzo, and neurotoxicity.The Lancet. Global health · 2017Article
- Vitamin B1 diversity and characterization of biosynthesis genes in cassava.Journal of experimental botany · 2017Article
- Bioavailability of cyanide after consumption of a single meal of foods containing high levels of cyanogenic glycosides: a crossover study in humans.Archives of toxicology · 2016Article
- Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo.PloS one · 2014Article
- Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.International journal of health geographics · 2013Article
- Pharmacovigilance of herbal medicines: the potential contributions of ethnobotanical and ethnopharmacological studies.Drug safety · 2013Article
- Interrelationships of undernutrition and neurotoxicity: food for thought and research attention.Neurotoxicology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tropical ataxic neuropathy (TAN) and epidemic spastic paraparesis (konzo) are two neurological disorders associated with the consumption of cassava (Manihot esculenta) in several African countries. TAN is characterized by sensory polyneuropathy, sensory ataxia, bilateral optic atrophy and bilateral sensori-neural deafness. It occurs in elderly individuals subsisting on a monotonous cassava diet with minimal protein supplementation. Konzo is a syndrome of symmetrical spastic paraparesis with a predilection for children and young women and invariably associated with consumption of inadequately processed bitter cassava roots with minimal protein supplementation. Despite numerous epidemiological, clinical and biochemical studies aimed at elucidating the etiological mechanisms of these disorders, their etiologies remain unknown, and there is no known treatment. The diseases continue to be prevalent in endemic areas, causing significant disability and increased mortality. A fresh appraisal of the putative etiologic mechanisms proposed for these intriguing and enigmatic syndromes is presented in this paper. Evidences against a causal role for cyanide intoxication are discussed, and evidences implicating thiamine deficiency as a unifying etiological mechanism for these neurological syndromes are presented. It is concluded that urgent research is needed to evaluate thiamine status and implement a therapeutic trial of thiamine in these debilitating neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.