ArticleMolecular bioSystems2011
Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler.
Article in Molecular bioSystems, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 90 citations in OpenAlex.
- Advances in large DNA fragment assembly for microbial cell factory engineering.Quantitative biology (Beijing, China) · 2026Review
- Gene-sized editing for the therapy of genetic diseases.Functional & integrative genomics · 2026Review
- Whole-genome sequencing and analysis of Streptomyces strains producing multiple antinematode drugs.BMC genomics · 2022Article
- Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides.Microbial cell factories · 2021Review
- New Set of Yeast Vectors for Shuttle Expression inACS omega · 2021Article
- Deletion of genomic islands in the Pseudomonas putida KT2440 genome can create an optimal chassis for synthetic biology applications.Microbial cell factories · 2020Article
- Protocols for yTREX/Tn5-based gene cluster expression in Pseudomonas putida.Microbial biotechnology · 2020Article
- Article
- Genetic platforms for heterologous expression of microbial natural products.Natural product reports · 2019Review
- Recent advances in natural products exploitation inEngineering in life sciences · 2019Review
- Heterologous expression-facilitated natural products' discovery in actinomycetes.Journal of industrial microbiology & biotechnology · 2019Review
- Recent Advances in Synthetic Biology Approaches to Optimize Production of Bioactive Natural Products in Actinobacteria.Frontiers in microbiology · 2019Review
- Rapid generation of recombinantSynthetic and systems biotechnology · 2017Article
- A Family of Single Copy repABC-Type Shuttle Vectors Stably Maintained in the Alpha-Proteobacterium Sinorhizobium meliloti.ACS synthetic biology · 2017Article
- Using natural products for drug discovery: the impact of the genomics era.Expert opinion on drug discovery · 2017Review
- Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring.ACS synthetic biology · 2017Article
- Engineering microbial hosts for production of bacterial natural products.Natural product reports · 2016Review
- Pathway Compartmentalization in Peroxisome of Saccharomyces cerevisiae to Produce Versatile Medium Chain Fatty Alcohols.Scientific reports · 2016Article
- New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.Natural product reports · 2016Review
- Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose.Microbial cell factories · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report a synthetic biology strategy for rapid genetic manipulation of natural product biosynthetic pathways. Based on DNA assembler, this method synthesizes the entire expression vector containing the target biosynthetic pathway and the genetic elements required for DNA maintenance and replication in various hosts in a single-step manner through yeast homologous recombination, offering unprecedented flexibility and versatility in pathway manipulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.