ArticleGut microbes
Probiotics and ileitis: could augmentation of TNF/NFκB activity be the answer?
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Alterations of the gut microbiota in coronavirus disease 2019 and its therapeutic potential.World journal of gastroenterology · 2022Review
- SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.British journal of pharmacology · 2018Article
- Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice.Molecules (Basel, Switzerland) · 2018Article
- Polysaccharides FromFrontiers in pharmacology · 2018Article
- The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.The Journal of pharmacology and experimental therapeutics · 2015Article
- Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.The Journal of nutritional biochemistry · 2014Article
- Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP.PloS one · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Probiotics have gained tremendous popularity amongst individuals searching for alternative and "natural" means to promote intestinal health. It has been suggested that the probiotic formulation VSL#3 promotes several aspects of intestinal health including attenuation of inflammatory bowel diseases (IBD). Although a definitive mechanism of action has not been clearly identified, it is generally accepted that probiotics suppress development of chronic inflammation by inhibiting activation of various inflammatory signaling pathways. This concept however needs to be revisited in light of a recent publication by Pagnini et al. showing that VSL#3 prevents development of ileitis through activation of NFκB and production of the prototypical inflammatory cytokine TNFα.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.