Evidence map›Paper›PMID 21326922›Full record

ReviewBioengineered bugs

Metabolic engineering of Saccharomyces cerevisiae for lactose/whey fermentation.

Lucília Domingues, Pedro M R Guimarães, Carla Oliveira

Open access · bronzeAbstract readReview
In one paragraph

Review in Bioengineered bugs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 83 citations in OpenAlex.

  1. Metabolic Engineering ofChem & bio engineering · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Evaluation ofFrontiers in microbiology · 2023
    Article
  6. Review
  7. Article
  8. Characterization of Cold-TolerantMicroorganisms · 2021
    Article
  9. Microbial Dynamics in Traditional and Modern Sour Beer Production.Applied and environmental microbiology · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Recent trends in bioethanol production from food processing byproducts.Journal of industrial microbiology & biotechnology · 2016
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lucília DominguesIBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, Braga, Portugal. luciliad@deb.uminho.pt
Pedro M R Guimarães
Carla Oliveira
Institute for Biotechnology and Bioengineering · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactose is an interesting carbon source for the production of several bio-products by fermentation, primarily because it is the major component of cheese whey, the main by-product of dairy activities. However, the microorganism more widely used in industrial fermentation processes, the yeast Saccharomyces cerevisiae, does not have a lactose metabolization system. Therefore, several metabolic engineering approaches have been used to construct lactose-consuming S. cerevisiae strains, particularly involving the expression of the lactose genes of the phylogenetically related yeast Kluyveromyces lactis, but also the lactose genes from Escherichia coli and Aspergillus niger, as reviewed here. Due to the existing large amounts of whey, the production of bio-ethanol from lactose by engineered S. cerevisiae has been considered as a possible route for whey surplus. Emphasis is given in the present review on strain improvement for lactose-to-ethanol bioprocesses, namely flocculent yeast strains for continuous high-cell-density systems with enhanced ethanol productivity.

Indexed as

Metabolic EngineeringEthanolFermentationLactoseMilk ProteinsSaccharomyces cerevisiaeWhey ProteinsEthanolLactoseMilk ProteinsWhey Proteinsbio-ethanolcheese wheyfermentationlactosemetabolic engineeringrecombinant Saccharomyces cerevisiae

Identifiers

PMID21326922
PMCPMC3026421
OpenAlexW2159613438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.