ArticleTranscription
B2 RNA represses TFIIH phosphorylation of RNA polymerase II.
Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Third-Generation Sequencing Reveals LncRNA-Regulated HSP Genes in theFrontiers in genetics · 2020Article
- Article
- Characters, functions and clinical perspectives of long non-coding RNAs.Molecular genetics and genomics : MGG · 2016Review
- Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth.PloS one · 2016Article
- lncRNAs in Stress Response.Current topics in microbiology and immunology · 2016Review
- The persistent contributions of RNA to eukaryotic gen(om)e architecture and cellular function.Cold Spring Harbor perspectives in biology · 2014Review
- Non-coding RNAs turn up the heat: an emerging layer of novel regulators in the mammalian heat shock response.Cell stress & chaperones · 2014Review
- Long noncoding RNAs as metazoan developmental regulators.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- The non-coding B2 RNA binds to the DNA cleft and active-site region of RNA polymerase II.Journal of molecular biology · 2013Article
- The intertwining of transposable elements and non-coding RNAs.International journal of molecular sciences · 2013Review
- Gene regulation by the act of long non-coding RNA transcription.BMC biology · 2013Review
- The regulation of mammalian mRNA transcription by lncRNAs: recent discoveries and current concepts.Epigenomics · 2013Article
- Non-coding RNAs: key regulators of mammalian transcription.Trends in biochemical sciences · 2012Review
- Transcription control by long non-coding RNAs.TranscriptionArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mouse B2 RNA represses RNA polymerase II (Pol II) transcription during the cellular heat shock response. B2 RNA binds Pol II, enters complexes at promoters, and keeps the polymerase from engaging the DNA. Here we show that phosphorylation of Ser5 residues in the Pol II carboxy terminal domain (CTD) decreases after heat shock at the promoter of the repressed actin gene in mouse cells, despite the continued presence of Cdk7 and cyclin H. Biochemical assays revealed that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.