Evidence map›Paper›PMID 21326906›Full record

ArticleTranscription

Genomic approaches for the discovery of CFTR regulatory elements.

Christopher J Ott, Ann Harris

Abstract read
In one paragraph

Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Molecular mechanisms controlling CFTR gene expression in the airway.Journal of cellular and molecular medicine · 2012
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher J OttHuman Molecular Genetics Program, Children's Memorial Research Center, Chicago, IL, USA.
Ann Harris

Funding

Tissue-specific regulation of a gene essential for normal airway epitheliaR01HL094585 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN · 2009 to 2020
$2.9M
NHLBI NIH HHS R01 HL094585
6 · The paper itself

Abstract

Non-coding regions of the human genome contain vast regulatory potential that contributes to the coordination of gene expression. Indeed, regulatory elements can reside large genomic distances from the promoters of genes they control. Here we describe approaches recently used to identify functional elements within the complex CFTR locus.

Indexed as

Binding SitesBlotting, SouthernChromatinChromatin ImmunoprecipitationCystic Fibrosis Transmembrane Conductance RegulatorDeoxyribonuclease IDNAGene Expression RegulationGenome, HumanGenomicsHumansInsulator ElementsIntronsPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidTranscription FactorsChromatinCystic Fibrosis Transmembrane Conductance RegulatorDeoxyribonuclease IDNATranscription FactorsCFTRchromosome conformation capture (3C)DNase-chipDNase I hypersensitivitytissue-specific enhancers

Identifiers

PMID21326906
PMCPMC3023643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.