Evidence map›Paper›PMID 21326903›Full record

ArticleTranscription

Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors.

Adam C Palmer, J Barry Egan, Keith E Shearwin

Abstract read
In one paragraph

Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Biophysical reviews · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. The Functional Meaning of 5'UTR in Protein-Coding Genes.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam C PalmerDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
J Barry Egan
Keith E Shearwin

Funding

Transcriptional Interference in Gene Regulatory DecisionsR01GM062976 · NIGMS · UNIVERSITY OF ADELAIDE · PI EGAN, JOHN BARRY · 2003 to 2008
$833k
NIGMS NIH HHS GM062976NIGMS NIH HHS R01 GM062976
6 · The paper itself

Abstract

Transcriptional interference is the in cis suppression of one transcriptional process by another. Mathematical modeling shows that promoter occlusion by elongating RNA polymerases cannot produce strong interference. Interference may instead be generated by (1) dislodgement of slow-to-assemble pre-initiation complexes and transcription factors and (2) prolonged occlusion by paused RNA polymerases.

Indexed as

AnimalsDNA-Directed RNA PolymerasesGene Expression RegulationHumansModels, GeneticPromoter Regions, GeneticProtein BindingTranscription FactorsTranscription, GeneticDNA-Directed RNA PolymerasesTranscription Factorsdislodgementgene regulationRNAP pausingtandem promoterstranscriptional interferencetranscription factorTRCF

Identifiers

PMID21326903
PMCPMC3023640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.