ArticlePloS one2011
Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Incorporating Intracellular Processes in Virus Dynamics Models.Microorganisms · 2024Review
- CD8Nature communications · 2023Article
- Early estimation of the number of hidden HIV infected subjects: An extended Kalman filter approach.Infectious Disease Modelling · 2023Article
- Control theory helps to resolve the measles paradox.Royal Society open science · 2021Article
- Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.Frontiers in immunology · 2020Article
- Towards multiscale modeling of the CD8Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- The dynamics of simian immunodeficiency virus after depletion of CD8+ cells.Immunological reviews · 2018Review
- Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8Journal of virology · 2018Article
- Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.The Journal of clinical investigation · 2018Article
- Prediction of the containment of HIV infection by antiretroviral therapy - a variable structure control approach.IET systems biology · 2017Article
- Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics.PLoS biology · 2016Article
- Notwithstanding Circumstantial Alibis, Cytotoxic T Cells Can Be Major Killers of HIV-1-Infected Cells.Journal of virology · 2016Article
- Modelling and Simulation of the Dynamics of the Antigen-Specific T Cell Response Using Variable Structure Control Theory.PloS one · 2016Article
- Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b).AIDS (London, England) · 2015Article
- How is the effectiveness of immune surveillance impacted by the spatial distribution of spreading infections?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Article
- The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.PLoS computational biology · 2014Article
- Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells.PLoS computational biology · 2014Article
- Article
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients infected with HIV exhibit orders of magnitude differences in their set-point levels of the plasma viral load. As to what extent this variation is due to differences in the efficacy of the cytotoxic T lymphocyte (CTL) response in these patients is unclear. Several studies have shown that HIV-infected CD4+ T cells also present viral epitopes that are recognized by CTLs before the productive stage of infection, i.e., during the intracellular eclipse phase before the infected cell starts to produce new viral particles. Here, we use mathematical modeling to investigate the potential impact of early killing of HIV-infected cells on viral replication. We suggest that the majority of CTL-mediated killing could occur during the viral eclipse phase, and that the killing of virus-producing cells could be substantially lower at later stages due to MHC-I-down-regulation. Such a mechanism is in agreement with several experimental observations that include CD8+ T cell depletion and antiretroviral drug treatment. This indicates a potentially important role of CTL-mediated killing during the non-productive stage of HIV-infected cells.
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