ArticleClinical epidemiology2011
Tuberculosis mortality in HIV-infected individuals: a cross-national systematic assessment.
Article in Clinical epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Trial
- Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium.Open forum infectious diseases · 2020Article
- Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccines.Nature communications · 2019Article
- Adrenal Insufficiency: A Forgotten Diagnosis in HIV/AIDS Patients in Developing Countries.International journal of endocrinology · 2019Review
- PCR-Internal Transcribed Spacer (ITS) genes sequencing and phylogenetic analysis of clinical and environmental Aspergillus species associated with HIV-TB co infected patients in a hospital in Abeokuta, southwestern Nigeria.African health sciences · 2016Article
- Antiretroviral Treatment Scale-Up and Tuberculosis Mortality in High TB/HIV Burden Countries: An Econometric Analysis.PloS one · 2016Article
- Mortality and causes of death among HIV-infected individuals in the country of Georgia: 1989-2012.AIDS research and human retroviruses · 2014Article
- Diabetes mellitus and risk of all-cause mortality among patients with tuberculosis in the state of Georgia, 2009-2012.Annals of epidemiology · 2014Article
- Barriers to and motivations for the implementation of a treatment programme for latent tuberculosis infection using isoniazid for people living with HIV, in upper northern Thailand.Global journal of health science · 2013Article
- Causes of mortality among tuberculosis and HIV co-infected patients in Chiang Rai, Northern Thailand.HIV/AIDS (Auckland, N.Z.) · 2012Article
- Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis.Bulletin of the World Health Organization · 2011Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTuberculosis (TB) is a leading cause of death in human immunodeficiency virus (HIV)-positive individuals. We sought to compare mortality rates in TB/HIV co-infected individuals globally and by country/territory.
designWe conducted a cross-national systematic assessment.
methodsTB mortality rates in HIV-positive and HIV-negative individuals were obtained from the World Health Organization (WHO) Stop TB department for 212 recognized countries/territories in the years 2006-2008. Multivariate linear regression determined the impact of health care resource and economic variables on our outcome variable, and TB mortality rates.
resultsIn 2008, an estimated 13 TB/HIV deaths occurred per 100,000 population globally with the African region having the highest death rate ([AFRH] ≥4% adult HIV-infection rate) at 86 per 100,000 individuals. The next highest rates were for the Eastern European Region (EEUR) and the Latin American Region (LAMR) at 4 and 3 respectively per 100,000 population. African countries' HIV-positive TB mortality rates were 29.9 times higher than non-African countries (95% confidence interval [CI]: 16.8-53.4). Every US$100 of government per capita health expenditure was associated with a 33% (95% CI: 24%-42%) decrease in TB/HIV mortality rates. The multivariate model also accounted for calendar year and did not include highly active antiretroviral therapy (HAART) coverage.
conclusionsOur results indicate that while the AFRH has the highest TB/HIV death rates, countries in EEUR and LAMR also have elevated mortality rates. Increasing health expenditure directed towards universal HAART access may reduce mortality from both diseases.
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