ArticlePloS one2011
Changes in brain size during the menstrual cycle.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Revealing the Neural Mechanism Underlying the Effects of Acupuncture on Migraine: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Trial
- Hormonal Modulation of Subjective Sleep Quality and Perivascular Space Volume Across the Menstrual Cycle: An Observational Dense-Sampling Study.bioRxiv : the preprint server for biology · 2026Article
- A prospective observational within-person MRI morphometric study comparing ictal and interictal brain volumes in status migrainosus.Neuroimage. Reports · 2026Article
- Factors Contributing to Short-Term Structural Variability in a Longitudinal MRI Dataset.Human brain mapping · 2026Article
- Progesterone-associated adjustments in brain structure during menstruation and the periovulatory phase-an MRI study.EBioMedicine · 2026Article
- Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.Brain communications · 2026Article
- Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals.Nature neuroscience · 2025Article
- Unveiling the Neurotransmitter Symphony: Dynamic Shifts in Neurotransmitter Levels during Menstruation.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Menstrual cycle-driven hormone concentrations co-fluctuate with white and gray matter architecture changes across the whole brain.Human brain mapping · 2024Article
- Estradiol and progesterone from pregnancy to postpartum: a longitudinal latent class analysis.Frontiers in global women's health · 2024Article
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Gray matter differences associated with menopausal hormone therapy in menopausal women: a DARTEL-based VBM study.Scientific reports · 2023Article
- Sex differences in brain structures throughout the lifetime.Aging brain · 2023Article
- Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms.Frontiers in neuroendocrinology · 2022Review
- Evaluation of functional MRI-based human brain parcellation: a review.Journal of neurophysiology · 2022Review
- Sex-specific multi-level 3D genome dynamics in the mouse brain.Nature communications · 2022Article
- Sex Hormones, Sleep, and Memory: Interrelationships Across the Adult Female Lifespan.Frontiers in aging neuroscience · 2022Review
- Structural and functional brain damage in women with multiple sclerosis: A mini-review of neuroimaging sex-based studies.Frontiers in neurology · 2022Review
- The epithelial potassium channel Kir7.1 is stimulated by progesterone.The Journal of general physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence for hormone-dependent modification of function and behavior during the menstrual cycle, but little is known about associated short-term structural alterations of the brain. Preliminary studies suggest that a hormone-dependent decline in brain volume occurs in postmenopausal, or women receiving antiestrogens, long term. Advances in serial MR-volumetry have allowed for the accurate detection of small volume changes of the brain. Recently, activity-induced short-term structural plasticity of the brain was demonstrated, challenging the view that the brain is as rigid as formerly believed. METHODOLOGY/PRINCIPAL
findingsWe used MR-volumetry to investigate short-term brain volume changes across the menstrual cycle in women or a parallel 4 week period in men, respectively. We found a significant grey matter volume peak and CSF loss at the time of ovulation in females. This volume peak did not correlate with estradiol or progesterone hormone levels. Men did not show any significant brain volume alterations. CONCLUSIONS/SIGNIFICANCE: These data give evidence of short-term hormone-dependent structural brain changes during the menstrual cycle, which need to be correlated with functional states and have to be considered in structure-associated functional brain research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.