ArticleGenes and immunity2011
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture.
Article in Genes and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Aberrant Enhancer Regulation, Phase Separation, and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2025Review
- Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method.Nature biotechnology · 2025Article
- PMF-GRN: a variational inference approach to single-cell gene regulatory network inference using probabilistic matrix factorization.Genome biology · 2024Article
- Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes.Frontiers in immunology · 2024Review
- The Role of Dynamic DNA Methylation in Liver Transplant Rejection in Children.Transplantation direct · 2022Article
- Distinct Molecular Mechanisms of Altered HLA Class II Expression in Malignant Melanoma.Cancers · 2021Article
- Epigenetic modification and therapeutic targets of diabetes mellitus.Bioscience reports · 2020Review
- Critical roles of super-enhancers in the pathogenesis of autoimmune diseases.Inflammation and regeneration · 2020Review
- Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus.International journal of molecular sciences · 2019Review
- SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions.Nucleic acids research · 2018Article
- DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.Nature communications · 2018Article
- Whole-Genome Cardiac DNA Methylation Fingerprint and Gene Expression Analysis Provide New Insights in the Pathogenesis of Chronic Chagas Disease Cardiomyopathy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Transancestral mapping and genetic load in systemic lupus erythematosus.Nature communications · 2017Article
- DNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus.Immunology · 2016Article
- Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach.International journal of molecular sciences · 2016Article
- MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Enhanced B Cell Alloantigen Presentation and Its Epigenetic Dysregulation in Liver Transplant Rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Article
- B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The intellectual disability of trisomy 21: differences in gene expression in a case series of patients with lower and higher IQ.European journal of human genetics : EJHG · 2013Article
- Using epigenetic mechanisms to understand the impact of common disease causing alleles.Current opinion in immunology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The major histocompatibility complex class II (MHC-II) locus encodes a cluster of highly polymorphic genes HLA-DR, -DQ and -DP that are co-expressed in mature B lymphocytes. Two cell lines were established over 30 years ago from a patient diagnosed with acute lymphocytic leukemia. Laz221 represented the leukemic cells of the patient; whereas Laz388 represented the normal B cells of the patient. Although Laz388 expressed both HLA-DR and HLA-DQ surface and gene products, Laz221 expressed only HLA-DR genes. The discordant expression of HLA-DR and HLA-DQ genes was due to epigenetic silencing of the HLA-DQ region CCCTC transcription factor (CTCF)-binding insulators that separate the MHC-II sub-regions by DNA methylation. These epigenetic modifications resulted in the loss of binding of the insulator protein CTCF to the HLA-DQ flanking insulator regions and the MHC-II-specific transcription factors to the HLA-DQ promoter regions. These events led to the inability of the HLA-DQ promoter regions to interact with flanking insulators that control HLA-DQ expression. Inhibition of DNA methylation by treatment with 5'-deoxyazacytidine reversed each of these changes and restored expression of the HLA-DQ locus. These results highlight the consequence of disrupting an insulator within the MHC-II region and may be a normal developmental mechanism or one used by tumor cells to escape immune surveillance.
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