ArticleThe Journal of investigative dermatology2011
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.
Article in The Journal of investigative dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.Nature genetics · 2012Pooled it
- Unraveling genetic predisposition and oxidative stress in vitiligo development and the role of artificial intelligence (AI) in diagnosis and management.Journal of medical biochemistry · 2025Article
- Inverse relationship between polygenic risk burden and age of onset of autoimmune vitiligo.American journal of human genetics · 2024Article
- Estimation of genetic variation in vitiligo associated genes: Population genomics perspective.BMC genomic data · 2024Article
- Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma.Infectious agents and cancer · 2024Article
- Aetiopathogenesis of Vitiligo.Dermatology practical & conceptual · 2023Review
- Contribution of HLA class II genes, DRB4*01:01, DRB1*07:01, and DQB1*03:03:2 to clinical features of Vitiligo disease in Iranian population.Molecular biology reports · 2022Article
- Uncovering Phenotypic Diversity and DArTseq Marker Loci Associated with Antioxidant Activity in Common Bean.Genes · 2019Article
- Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/β-catenin signaling.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Clinical and Molecular Aspects of Vitiligo Treatments.International journal of molecular sciences · 2018Review
- Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy.Clinical reviews in allergy & immunology · 2018Review
- Genetics of Vitiligo.Dermatologic clinics · 2017Review
- Article
- The role of IL-17 in vitiligo: A review.Autoimmunity reviews · 2016Review
- Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci.Frontiers in genetics · 2016Review
- Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo.The Journal of investigative dermatology · 2015Article
- Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures.The Journal of investigative dermatology · 2015Article
- Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model.BMC genomics · 2014Article
- Current aspects of vitiligo genetics.Postepy dermatologii i alergologii · 2014Review
- Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci.The Journal of clinical endocrinology and metabolism · 2014Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 5 countries.
Funding
Abstract
Generalized vitiligo is a common autoimmune disease in which acquired patchy depigmentation of skin, hair, and mucous membranes results from loss of melanocytes from involved areas. Previous genetic analyses have focused on vitiligo susceptibility, and have identified a number of genes involved in disease risk. Age of onset of generalized vitiligo also involves a substantial genetic component, but has not previously been studied systematically. In this study, we report a genome-wide association study of vitiligo age of onset in 1,339 generalized vitiligo patients, with replication in an independent cohort of 677 cases. We identified a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MHC) class II region, located near c6orf10-BTNL2 (rs7758128; P=8.14 × 10(-11)), a region that is also associated with generalized vitiligo susceptibility. In contrast, there was no association of vitiligo age of onset with any other MHC or non-MHC loci that are associated with vitiligo susceptibility. These findings highlight the differing roles played by genes involved in vitiligo susceptibility versus vitiligo age of onset, and illustrate that genome-wide analyses can be used to identify genes involved in quantitative aspects of disease natural history, as well as disease susceptibility per se.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.