Evidence map›Paper›PMID 21326262›Full record

ArticleClinical pharmacology and therapeutics2011

Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practice.

R A Schnoll, A E Shields

Abstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Pharmacogenetic testing: Current Evidence of Clinical Utility.Therapeutic advances in drug safety · 2013
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R A SchnollDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. schnoll@mail.med.upenn.edu
A E Shields

Funding

University of Toronto Coordinating Genetics Core & Clinical Trial SiteU01DA020830 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI HATSUKAMI, DOROTHY K · 2005 to 2014
$22.4M
An Effectiveness Trial of Maintenance Therapy for Nicotine DependenceR01DA025078 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT ADAM · 2009 to 2013
$3.1M
Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of NicotineR21DA026889 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT ADAM · 2009 to 2010
$433k
Efficacy of Varenicline for Smokless Tobacco Use in IndiaR21DA026404 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT ADAM · 2010 to 2011
$385k
NCI NIH HHS CA 126989NIDA NIH HHS DA 020830NIDA NIH HHS DA 025078NIDA NIH HHS DA 02585NIDA NIH HHS DA 026404NIDA NIH HHS DA 026889NIDA NIH HHS R01 DA025078NIDA NIH HHS R21 DA026404NIDA NIH HHS R21 DA026889NIDA NIH HHS U01 DA020830
6 · The paper itself

Abstract

Advances in genomics research may improve health outcomes by tailoring treatment according to patients' genetic profiles. The treatment of nicotine dependence, in particular, may soon encompass pharmacogenetic treatment models. Realizing the benefits of such treatment strategies may depend on physicians' preparedness to incorporate genetic testing into clinical practice. This article describes barriers to clinical integration of pharmacogenetic treatments that will need to be addressed to realize the benefits of individualized smoking-cessation treatment.

Indexed as

Attitude of Health PersonnelPharmacogeneticsGenetic ResearchHumansPractice Patterns, Physicians'Precision MedicinePrimary Health CareSmokingSmoking CessationSmoking PreventionTobacco Use Disorder

Identifiers

PMID21326262
PMCPMC3184286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.