ArticleThe EMBO journal2011
Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 77 citations in OpenAlex.
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- Upstream CtrA-binding sites both induce and repress pilin gene expression in Caulobacter crescentus.BMC genomics · 2024Article
- Regulation of biofilm gene expression by DNA replication in Bacillus subtilis.Journal of cellular and molecular medicine · 2024Article
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- Comparative transcriptomics reveal different genetic adaptations of biofilm formation inFrontiers in microbiology · 2022Article
- Calcium Prevents Biofilm Dispersion in Bacillus subtilis.Journal of bacteriology · 2021Article
- Topography and Expansion Patterns at the Biofilm-Agar Interface inMicroorganisms · 2020Article
- Negative Interplay between Biofilm Formation and Competence in the Environmental Strains ofmSystems · 2020Article
- Mitigating Milk-Associated Bacteria through Inducing Zinc Ions Antibiofilm Activity.Foods (Basel, Switzerland) · 2020Article
- The Adaptive Morphology ofMicroorganisms · 2019Article
- Biofilms Positively Contribute toInternational journal of molecular sciences · 2019Article
- Stochastic antagonism between two proteins governs a bacterial cell fate switch.Science (New York, N.Y.) · 2019Article
- A Decrease in Serine Levels during Growth Transition Triggers Biofilm Formation in Bacillus subtilis.Journal of bacteriology · 2019Article
- ResDE Two-Component Regulatory System Mediates Oxygen Limitation-Induced Biofilm Formation by Bacillus amyloliquefaciens SQR9.Applied and environmental microbiology · 2018Article
- Pleiotropic roles of Clostridium difficile sin locus.PLoS pathogens · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bacillus subtilis chooses between matrix production and spore formation, which are both controlled by the regulator Spo0A~P. We report that metabolism and chromosome copy number dictate which fate is adopted. Conditions that favour low Spo0A~P levels promote matrix production, whereas conditions favouring high levels trigger sporulation. Spo0A~P directs the synthesis of SinI, an antirepressor for the SinR repressor of matrix genes. The regulatory region of sinI contains an activator site that Spo0A~P binds strongly and operators that bind Spo0A~P weakly. Evidence shows that low Spo0A~P levels turn sinI ON and high levels turn sinI OFF and instead switch sporulation ON. Cells in which sinI and sinR were transplanted from their normal position near the chromosome replication terminus to positions near the origin and cells that harboured an extra copy of the genes were blocked in matrix production. Thus, matrix gene expression is sensitive to the number of copies of sinI and sinR. Because cells at the start of sporulation have two chromosomes and matrix-producing cells one, chromosome copy number could contribute to cell-fate determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.