ArticleThe EMBO journal2011
The Arabidopsis peptide kiss of death is an inducer of programmed cell death.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 103 citations in OpenAlex.
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- Quantitative Assessment of Heat Shock-Induced Ferroptosis-Like Cell Death via Electrolyte Leakage inBio-protocol · 2026Article
- Plant non-canonical peptides: From identification to mechanisms.Plant communications · 2026Review
- The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.Plant communications · 2025Review
- Biological Activity of Artificial Plant Peptides Corresponding to the Translational Products of Small ORFs in Primary miRNAs and Other Long "Non-Coding" RNAs.Plants (Basel, Switzerland) · 2024Review
- Transcriptional and translational landscape fine-tune genome annotation and explores translation control in cotton.Journal of advanced research · 2024Article
- Plant cathepsin B, a versatile protease.Frontiers in plant science · 2024Review
- The F-box protein UFO controls flower development by redirecting the master transcription factor LEAFY to new cis-elements.Nature plants · 2023Article
- Small open reading frames in plant research: from prediction to functional characterization.3 Biotech · 2022Review
- LncRNA-Encoded Short Peptides Identification Using Feature Subset Recombination and Ensemble Learning.Interdisciplinary sciences, computational life sciences · 2022Article
- Pervasive translation of small open reading frames in plant long non-coding RNAs.Frontiers in plant science · 2022Review
- Peptidome: Chaos or Inevitability.International journal of molecular sciences · 2021Review
- The computational approaches of lncRNA identification based on coding potential:Computational and structural biotechnology journal · 2020Review
- Distinct types of short open reading frames are translated in plant cells.Genome research · 2019Article
- The Tomato Translational Landscape Revealed by Transcriptome Assembly and Ribosome Profiling.Plant physiology · 2019Article
- Plant proteases during developmental programmed cell death.Journal of experimental botany · 2019Review
- Coding or Noncoding, the Converging Concepts of RNAs.Frontiers in genetics · 2019Review
- Article
- Nitrogen Source Dependent Changes in Central Sugar Metabolism Maintain Cell Wall Assembly in Mitochondrial Complex I-DefectiveInternational journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Programmed cell death (PCD) has a key role in defence and development of all multicellular organisms. In plants, there is a large gap in our knowledge of the molecular machinery involved at the various stages of PCD, especially the early steps. Here, we identify kiss of death (KOD) encoding a 25-amino-acid peptide that activates a PCD pathway in Arabidopsis thaliana. Two mutant alleles of KOD exhibited a reduced PCD of the suspensor, a single file of cells that support embryo development, and a reduced PCD of root hairs after a 55°C heat shock. KOD expression was found to be inducible by biotic and abiotic stresses. Furthermore, KOD expression was sufficient to cause death in leaves or seedlings and to activate caspase-like activities. In addition, KOD-induced PCD required light in leaves and was repressed by the PCD-suppressor genes AtBax inhibitor 1 and p35. KOD expression resulted in depolarization of the mitochondrial membrane, placing KOD above mitochondria dysfunction, an early step in plant PCD. A KOD∷GFP fusion, however, localized in the cytosol of cells and not mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.