ArticleIslets
Low insulin content of large islet population is present in situ and in isolated islets.
Article in Islets. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Influence of islet purity on the proportion of smaller islets and graft outcomes in clinical transplantation.World journal of transplantation · 2026Review
- Effects of Intermittent Fasting-Mimicking Diet on Pancreatic Islet Plasticity: Immunohistochemical, Ultrastructural, and Metabolic Profiles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Aldosterone induced by chronic stress promotes pancreatic steatosis in young male rats.Cell and tissue research · 2026Article
- Islet dimension and its impact on transplant outcome: A systematic review.World journal of transplantation · 2025Article
- Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA.Nature communications · 2024Article
- Long-Term Administration of Omeprazole-Induced Hypergastrinemia and Changed Glucose Homeostasis and Expression of Metabolism-Related Genes.BioMed research international · 2024Article
- A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome.Biomedicines · 2023Review
- The nuclear localization sequence and C-terminus of parathyroid hormone-related protein regulate normal pancreatic islet development and function.General and comparative endocrinology · 2023Article
- Maternal perinatal exposure to bisphenol S induces an estrogenic like effect in glucose homeostasis in male offspring.Environmental toxicology · 2022Article
- (-)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality.Planta medica · 2022Article
- PEGDA microencapsulated allogeneic islets reverse canine diabetes without immunosuppression.PloS one · 2022Article
- A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance.Science advances · 2021Article
- 3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II.Disease models & mechanisms · 2020Article
- A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes.Science advances · 2020Article
- Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes.Communications biology · 2020Article
- The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.Journal of diabetes research · 2019Article
- Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.Diabetologia · 2018Article
- CD146 positive human dental pulp stem cells promote regeneration of dentin/pulp-like structures.Human cell · 2018Article
- Integration of mesenchymal stem cells into islet cell spheroids improves long-term viability, but not islet function.Islets · 2017Article
- Intra-islet lesions and lobular variations in β-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The existence of morphologically distinct populations of islets in the pancreas was described over 60 years ago. Unfortunately, little attention has been paid to possible functional differences between islet subpopulations until recently. We demonstrated that one population, the small islets, were superior to large islets in a number of functional aspects. However, that work did not determine whether these differences were inherent, or whether they arose because of the challenge of isolation procedures. Nor, were there data to explain the differences in insulin secretion. We utilized immunohistochemistry, immunofluorescence, ELISA, and transmission electron microscopy to compare the unique characteristics found in isolated rat islet populations in situ and after isolation. Insulin secretion of small isolated islets was significantly higher compared to large islets, which correlated with higher insulin content/area in small islets (in situ), a higher density of insulin secretory granules, and greater insulin content/volume in isolated islets. Specifically, the core b-cells of the large islets contained less insulin/cell with a lower insulin granule density than peripheral b-cells. When insulin secretion was normalized for total insulin content, large and small islets released the same percentage of total insulin. Small islets had a higher density of cells/area than large islets in vitro and in situ. The data provide a possible explanation for the inferior insulin secretion from large islets, as they have a lower total cell density and the b-cells of the core contain less insulin/cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.