ArticleMolecular biology of the cell2011
Hairless is a cofactor for Runt-dependent transcriptional regulation.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Genetic and Molecular Interactions betweenGenes · 2023Article
- Article
- Evidence That Runt Acts as a Counter-Repressor of Groucho DuringG3 (Bethesda, Md.) · 2020Article
- The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum.BMC genomics · 2018Article
- Role of co-repressor genomic landscapes in shaping the Notch response.PLoS genetics · 2017Article
- Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.PLoS genetics · 2017Article
- Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development.PloS one · 2016Article
- Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.PloS one · 2015Article
- Evolution of the pair rule gene network: Insights from a centipede.Developmental biology · 2013Article
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Authors and funding
3 authors.
Funding
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Abstract
Runt is a vital transcriptional regulator in the developmental pathway responsible for segmentation in the Drosophila embryo. Runt activates or represses transcription in a manner that is dependent on both cellular context and the specific downstream target. Here we identify Hairless (H) as a Runt-interacting molecule that functions during segmentation. We find that H is important for maintenance of engrailed (en) repression as was previously demonstrated for Groucho (Gro), Rpd3, and CtBP. H also contributes to the Runt-dependent repression of sloppy-paired-1 (slp1), a role that is not shared with these other corepressors. We further find distinct roles for these different corepressors in the regulation of other Runt targets in the early Drosophila embryo. These findings, coupled with observations on the distinct functional requirements for Runt in regulating these several different targets, indicate that Runt-dependent regulation in the Drosophila blastoderm embryo relies on unique, target-gene-specific molecular interactions.
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