ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Noradrenergic input to hypoglossal motoneurons is mediated by interneurons located in prehypoglossal region.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.Nature communications · 2025Article
- Cross-Frequency Slow Oscillation-Spindle Coupling in a Biophysically Realistic Thalamocortical Neural Mass Model.Frontiers in computational neuroscience · 2022Article
- Sleep Disturbances and Depression Are Co-morbid Conditions: Insights From Animal Models, Especially Non-human Primate Model.Frontiers in psychiatry · 2021Review
- Sleep-Wake Neurobiology.Advances in experimental medicine and biology · 2021Review
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- Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States.Frontiers in neuroscience · 2020Article
- Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.Journal of circadian rhythms · 2019Article
- GABA is a modulator, rather than a classical transmitter, in the medial nucleus of the trapezoid body-lateral superior olive sound localization circuit.The Journal of physiology · 2019Article
- Article
- The Neurobiology of Anesthetic Emergence.Journal of neurosurgical anesthesiology · 2016Review
- Alcohol disrupts sleep homeostasis.Alcohol (Fayetteville, N.Y.) · 2015Review
- Article
- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- Fast detection of extrasynaptic GABA with a whole-cell sniffer.Frontiers in cellular neuroscience · 2014Article
- Methods for recording and measuring tonic GABAA receptor-mediated inhibition.Frontiers in neural circuits · 2013Review
- Sleep and Anesthesia Interactions: A Pharmacological Appraisal.Current anesthesiology reports · 2013Article
- Article
- Hypocretinergic and non-hypocretinergic projections from the hypothalamus to the REM sleep executive area of the pons.Brain research · 2013Article
- GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep.Sleep · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Studies using drugs that increase or decrease GABAergic transmission suggest that GABA in the pontine reticular formation (PRF) promotes wakefulness and inhibits rapid eye movement (REM) sleep. Cholinergic transmission in the PRF promotes REM sleep, and levels of endogenous acetylcholine (ACh) in the PRF are significantly greater during REM sleep than during wakefulness or non-REM (NREM) sleep. No previous studies have determined whether levels of endogenous GABA in the PRF vary as a function of sleep and wakefulness. This study tested the hypothesis that GABA levels in cat PRF are greatest during wakefulness and lowest during REM sleep. Extracellular GABA levels were measured during wakefulness, NREM sleep, REM sleep, and the REM sleep-like state (REM(Neo)) caused by microinjecting neostigmine into the PRF. GABA levels varied significantly as a function of sleep and wakefulness, and decreased significantly below waking levels during REM sleep (-42%) and REM(Neo) (-63%). The decrease in GABA levels during NREM sleep (22% below waking levels) was not statistically significant. Compared with NREM sleep, GABA levels decreased significantly during REM sleep (-27%) and REM(Neo) (-52%). Comparisons of REM sleep and REM(Neo) revealed no differences in GABA levels or cortical EEG power. GABA levels did not vary significantly as a function of dialysis site within the PRF. The inverse relationship between changes in PRF levels of GABA and ACh during REM sleep indicates that low GABAergic tone combined with high cholinergic tone in the PRF contributes to the generation of REM sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.