ArticleAmerican journal of physiology. Renal physiology2011
Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels.Pflugers Archiv : European journal of physiology · 2025Trial
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- Inhibition of renalase drives tumour rejection by promoting T cell activation.European journal of cancer (Oxford, England : 1990) · 2022Article
- Identification of Two Forms of Human Plasma Renalase, and Their Association With All-Cause Mortality.Kidney international reports · 2020Article
- Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- The Relationship between Sleep Bruxism Intensity and Renalase Concentration-An Enzyme Involved in Hypertension Development.Journal of clinical medicine · 2019Article
- Dietary Phosphorus Intake and the Kidney.Annual review of nutrition · 2017Review
- Extracellular renalase protects cells and organs by outside-in signalling.Journal of cellular and molecular medicine · 2017Review
- Acute Adaption to Oral or Intravenous Phosphate Requires Parathyroid Hormone.Journal of the American Society of Nephrology : JASN · 2017Article
- Serum renalase is related to catecholamine levels and renal function.Clinical and experimental nephrology · 2015Article
- Renalase: its role as a cytokine, and an update on its association with type 1 diabetes and ischemic stroke.Current opinion in nephrology and hypertension · 2014Review
- Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases.Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- Regulation of renalase expression by D5 dopamine receptors in rat renal proximal tubule cells.American journal of physiology. Renal physiology · 2014Article
- The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.Pflugers Archiv : European journal of physiology · 2013Article
- Renalase regulates renal dopamine and phosphate metabolism.American journal of physiology. Renal physiology · 2013Article
- NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones.American journal of physiology. Renal physiology · 2012Article
- Article
- Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study.American journal of nephrology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The current experiments explore the role of dopamine in facilitating the acute increase in renal phosphate excretion in response to a high-phosphate diet. Compared with a low-phosphate (0.1%) diet for 24 h, mice fed a high-phosphate (1.2%) diet had significantly higher rates of phosphate excretion in the urine associated with a two- to threefold increase in the dopamine content of the kidney and in the urinary excretion of dopamine. Animals fed a high-phosphate diet had a significant increase in the abundance and activity of renal DOPA (l-dihydroxyphenylalanine) decarboxylase and significant reductions in renalase, monoamine oxidase A, and monoamine oxidase B. The activity of protein kinase A and protein kinase C, markers of activation of renal dopamine receptors, were significantly higher in animals fed a high-phosphate vs. a low-phosphate diet. Treatment of rats with carbidopa, an inhibitor of DOPA decarboxylase, impaired adaptation to a high-phosphate diet. These experiments indicate that the rapid adaptation to a high-phosphate diet involves alterations in key enzymes involved in dopamine synthesis and degradation, resulting in increased renal dopamine content and activation of the signaling cascade used by dopamine to inhibit the renal tubular reabsorption of phosphate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.