ArticleThe Plant cell2011
Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100 citing papers in PubMed, 200 citations in OpenAlex.
- Distinct associations of ScGDD1/BC12 transcript abundance and sequence variation with grain size and shape in rye.Journal of applied genetics · 2026Article
- Class I TCP transcription factor OsTCP4 suppresses plant height via negatively regulating the green revolution genePlant diversity · 2026Article
- Genetic mapping and isolation of Rht28, a locus on wheat chromosome arm 2AL affecting plant height, grain size, and grain weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A MYB61-SWB9-KOs module regulates grain chalkiness via gibberellin biosynthesis in rice endosperm.Plant biotechnology journal · 2025Article
- Feedback transcription regulation between OsNAC3 and OsDREB1A promotes postgermination growth in rice.Science advances · 2025Article
- Diverse roles of ethylene in maize growth and development, and its importance in shaping plant architecture.Journal of experimental botany · 2025Review
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- Unraveling the Complexities of Flowering in Ornamental Plants: The Interplay of Genetics, Hormonal Networks, and Microbiome.Plants (Basel, Switzerland) · 2025Review
- Dwarfs standing tall: breeding towards the 'Yellow revolution' through insights into plant height regulation.Plant molecular biology · 2025Review
- Overexpression of the general transcription factor OsTFIIB5 alters rice development and seed quality.Plant cell reports · 2025Article
- Reference genome sequence and population genomic analysis of peas provide insights into the genetic basis of Mendelian and other agronomic traits.Nature genetics · 2024Article
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- Genetic architecture and genomic prediction of plant height-related traits in chrysanthemum.Horticulture research · 2024Article
- Assessment of genetic structure and trait associations of Watkins wheat landraces under Egyptian field conditions.Frontiers in genetics · 2024Article
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- Genetic Basis of Grain Size and Weight in Rice, Wheat, and Barley.International journal of molecular sciences · 2023Review
- An LTR retrotransposon insertion inside CsERECTA for an LRR receptor-like serine/threonine-protein kinase results in compact (cp) plant architecture in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Kinesins Modify ERR1-Dependent Transcription Using a Conserved Nuclear Receptor Box Motif.International journal of molecular sciences · 2023Article
- Article
- CEF3 is involved in membrane trafficking and essential for secondary cell wall biosynthesis and its mutation enhanced biomass enzymatic saccharification in rice.Biotechnology for biofuels and bioproducts · 2022Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinesins are a family of microtubule-based motor proteins that move directionally along microtubules and are involved in many crucial cellular processes, including cell elongation in plants. Less is known about kinesins directly regulating gene transcription to affect cellular physiological processes. Here, we describe a rice (Oryza sativa) mutant, gibberellin-deficient dwarf1 (gdd1), that has a phenotype of greatly reduced length of root, stems, spikes, and seeds. This reduced length is due to decreased cell elongation and can be rescued by exogenous gibberellic acid (GA₃) treatment. GDD1 was cloned by a map-based approach, was expressed constitutively, and was found to encode the kinesin-like protein BRITTLE CULM12 (BC12). Microtubule cosedimentation assays revealed that BC12/GDD1 bound to microtubules in an ATP-dependent manner. Whole-genome microarray analysis revealed the expression of ent-kaurene oxidase (KO2), which encodes an enzyme involved in GA biosynthesis, was downregulated in gdd1. Electrophoretic mobility shift and chromatin immunoprecipitation assays revealed that GDD1 bound to the element ACCAACTTGAA in the KO2 promoter. In addition, GDD1 was shown to have transactivation activity. The level of endogenous GAs was reduced in gdd1, and the reorganization of cortical microtubules was altered. Therefore, BC12/GDD1, a kinesin-like protein with transcription regulation activity, mediates cell elongation by regulating the GA biosynthesis pathway in rice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.