ArticleJournal of cell science2011
Drosophila male germline stem cells do not asymmetrically segregate chromosome strands.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Non-random Sister Chromatid Segregation Mediated by Ribosomal DNA in Drosophila Male Germline Stem Cells.Advances in experimental medicine and biology · 2026Review
- Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication-coupled histone incorporation.Science advances · 2025Article
- Cellular and molecular mechanisms of asymmetric stem cell division in tissue homeostasis.Genes to cells : devoted to molecular & cellular mechanisms · 2024Review
- RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila.PLoS genetics · 2024Article
- The adult Drosophila testis lacks a mechanism to replenish missing niche cells.Development (Cambridge, England) · 2023Article
- Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage.Developmental cell · 2022Article
- Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells.Cell reports · 2020Article
- Asymmetric Histone Inheritance in Asymmetrically Dividing Stem Cells.Trends in genetics : TIG · 2020Review
- Asymmetric Centromeres Differentially Coordinate with Mitotic Machinery to Ensure Biased Sister Chromatid Segregation in Germline Stem Cells.Cell stem cell · 2019Article
- Emerging mechanisms of asymmetric stem cell division.The Journal of cell biology · 2018Review
- Protecting and Diversifying the Germline.Genetics · 2018Review
- When stem cells grow old: phenotypes and mechanisms of stem cell aging.Development (Cambridge, England) · 2016Review
- Article
- Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity.Biology open · 2015Article
- Epigenetic regulation of germ cells-remember or forget?Current opinion in genetics & development · 2015Review
- Stem cell decisions: a twist of fate or a niche market?Seminars in cell & developmental biology · 2014Review
- The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.Development (Cambridge, England) · 2014Article
- Lineage tracing quantification reveals symmetric stem cell division in Drosophila male germline stem cells.Cellular and molecular bioengineering · 2013Article
- Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines.Molecular cancer · 2013Article
- DNA asymmetry in stem cells - immortal or mortal?Journal of cell science · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adult stem cells continuously supply differentiated cells throughout the life of organisms. This increases the risk of replicative senescence or neoplastic transformation due to mutations that accumulate over many rounds of DNA replication. The immortal strand hypothesis proposes that stem cells reduce the accumulation of replication-induced mutations by retaining the older template DNA strands. Other models have also been proposed in which stem cells asymmetrically segregate chromosome strands for other reasons, such as retention of epigenetic memories. Recently, the idea has emerged that the mother centrosome, which is stereotypically retained within some asymmetrically dividing stem cells, might be utilized as a means of asymmetrically segregating chromosome strands. We have tested this hypothesis in germline stem cells (GSCs) from Drosophila melanogaster testis, which undergo asymmetric divisions marked by the asymmetric segregation of centrosomes and the acquisition of distinct daughter cell fates (stem cell self-renewal versus differentiation). Using 5-bromo-2-deoxyuridine labeling combined with direct visualization of GSC-gonialblast (differentiating daughter) pairs, we directly scored the outcome of chromosome strand segregation. Our data show that, in male GSCs in the Drosophila testis, chromosome strands are not asymmetrically segregated, despite asymmetrically segregating centrosomes. Our data demonstrate that asymmetric centrosome segregation in stem cells does not necessarily lead to asymmetric chromosome strand segregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.