ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2011
Dietary and supplemental intake of one-carbon nutrients and the risk of type I and type II endometrial cancer: a prospective cohort study.
Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review.Familial cancer · 2019Pooled it
- Nutritional Interventions to Improve Clinical Outcomes in Ovarian Cancer: A Systematic Review of Randomized Controlled Trials.Nutrients · 2019Pooled it
- Folate intake and the risk of endometrial cancer: A meta-analysis.Oncotarget · 2016Pooled it
- Vitamins in Gynecologic Malignancies.Nutrients · 2024Review
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Elevated Expression of Gamma-Glutamyl Hydrolase Is Associated With Poor Prognosis and Altered Immune Signature in Uterine Corpus Endometrial Carcinoma.Frontiers in genetics · 2021Article
- Excess Body Weight and Incidence of Type 1 and Type 2 Endometrial Cancer: The Norwegian Women and Cancer Study.Clinical epidemiology · 2020Article
- Dietary intake of nutrients involved in folate-mediated one-carbon metabolism and risk for endometrial cancer.International journal of epidemiology · 2019Article
- The Revised D-A-CH-Reference Values for the Intake of Vitamin BMolecular nutrition & food research · 2019Article
- Overexpression of the matrix metalloproteinase 11 gene is a potential biomarker for type 1 endometrial cancer.Oncology letters · 2018Article
- Dietary Reference Values for riboflavin.EFSA journal. European Food Safety Authority · 2017Article
- Food Fortification and Supplement Use-Are There Health Implications?Critical reviews in food science and nutrition · 2016Review
- Sugar-sweetened beverage intake and the risk of type I and type II endometrial cancer among postmenopausal women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.British journal of cancer · 2013Article
- Type I and II endometrial cancers: have they different risk factors?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Review
- One-carbon metabolism factors and endometrial cancer risk.British journal of cancer · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundType I and II endometrial cancer are biologically and clinically distinct, with type II cancers having a high frequency of p53 mutations and an association with chromosomal instability. This raises the hypothesis that one-carbon nutrients (folate, methionine, and the enzymic cofactors vitamins B2, B6, and B12), which mediate chromosomal stability and DNA methylation, may be protective for type II but not type I endometrial cancer.
methodsUsing a prospective cohort of 23 356 postmenopausal women followed 20 years, we estimated the relative risks (RRs) of type I (N = 471) and II (N = 71) endometrial cancers according to intake of one-carbon nutrients, adjusting for confounders.
resultsNo associations were observed between dietary or supplemental intake of any one-carbon nutrient and risk of type I cancer. For type II cancer, positive associations were due to supplemental, rather than dietary, intake of these nutrients: supplemental folate (RR = 1.80 for >228.6 versus 0 μg/day; P trend = 0.027) and vitamins B2 (RR = 1.94 for >1.70 versus 0 mg/day; P trend = 0.011), B6 (RR = 2.08 for >2.00 versus 0 mg/day; P trend = 0.012), and B12 (RR = 2.10 for >3.43 versus 0 μg/day; P trend = 0.0060).
conclusionContrary to our hypothesis, use of supplements containing folate and vitamins B2, B6, and B12 was associated with an increased risk of type II endometrial cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.