ArticleDisease models & mechanisms2011
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity.
Article in Disease models & mechanisms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mapping novel QTL and fine mapping of previously identified QTL associated with glucose tolerance using the collaborative cross mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- GWAS Central: an expanding resource for finding and visualising genotype and phenotype data from genome-wide association studies.Nucleic acids research · 2023Article
- Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide.Scientific reports · 2022Article
- Insight into genetic, biological, and environmental determinants of sexual-dimorphism in type 2 diabetes and glucose-related traits.Frontiers in cardiovascular medicine · 2022Review
- Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment.BMC genetics · 2020Article
- GWAS Central: a comprehensive resource for the discovery and comparison of genotype and phenotype data from genome-wide association studies.Nucleic acids research · 2020Article
- Review
- Genetics of Cardiovascular Disease: Fishing for Causality.Frontiers in cardiovascular medicine · 2018Review
- Glucose tolerance female-specific QTL mapped in collaborative cross mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.The Journal of endocrinology · 2016Review
- The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.The Journal of biological chemistry · 2015Article
- Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.Human genetics · 2015Review
- Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.Genome research · 2015Article
- Review
- Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.World journal of diabetes · 2014Review
- Article
- Article
- From mice to humans.Current diabetes reports · 2012Review
- Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.Diabetologia · 2012Article
- The use of animal models in diabetes research.British journal of pharmacology · 2012Article
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2 authors.
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Abstract
Within the last 3 years, genome-wide association studies (GWAS) have had unprecedented success in identifying loci that are involved in common diseases. For example, more than 35 susceptibility loci have been identified for type 2 diabetes and 32 for obesity thus far. However, the causal gene and variant at a specific linkage disequilibrium block is often unclear. Using a combination of different mouse alleles, we can greatly facilitate the understanding of which candidate gene at a particular disease locus is associated with the disease in humans, and also provide functional analysis of variants through an allelic series, including analysis of hypomorph and hypermorph point mutations, and knockout and overexpression alleles. The phenotyping of these alleles for specific traits of interest, in combination with the functional analysis of the genetic variants, may reveal the molecular and cellular mechanism of action of these disease variants, and ultimately lead to the identification of novel therapeutic strategies for common human diseases. In this Commentary, we discuss the progress of GWAS in identifying common disease loci for metabolic disease, and the use of the mouse as a model to confirm candidate genes and provide mechanistic insights.
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