ArticleGenome research2011
A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes.
Article in Genome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 139 citations in OpenAlex.
- Trial
- Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Trial
- Pluripotent stem cell-specific imprinted genes identified using human uniparental-induced pluripotent stem cells.Journal of advanced research · 2026Article
- Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci.Cell proliferation · 2026Article
- Dynamic allelic expression in mouse mammary glands across the adult developmental cycle.Nucleic acids research · 2025Article
- ImprintCap, a powerful NGS-based technology to investigate the molecular background of imprinting disorders.Clinical epigenetics · 2025Article
- Clinical and genetic analysis of pseudohypoparathyroidism complicated by hypokalemia: a case report and review of the literature.BMC endocrine disorders · 2022Review
- A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates.BMC biology · 2022Article
- Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.British journal of cancer · 2021Article
- DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.Clinical epigenetics · 2019Article
- Novel parent-of-origin-specific differentially methylated loci on chromosome 16.Clinical epigenetics · 2019Article
- Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.Human molecular genetics · 2019Article
- Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome.Human molecular genetics · 2019Article
- Submicroscopic aberrations of chromosome 16 in prenatal diagnosis.Molecular cytogenetics · 2019Article
- Epigenetic regulation in development: is the mouse a good model for the human?Human reproduction update · 2018Review
- Maternal 5Frontiers in genetics · 2018Article
- Novel imprinted single CpG sites found by global DNA methylation analysis in human parthenogenetic induced pluripotent stem cells.Epigenetics · 2018Article
- Wilms tumour in Beckwith-Wiedemann Syndrome and loss of methylation at imprinting centre 2: revisiting tumour surveillance guidelines.European journal of human genetics : EJHG · 2017Article
- Epigenetic basis of cancer health disparities: Looking beyond genetic differences.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Allelic Dropout During Polymerase Chain Reaction due to G-Quadruplex Structures and DNA Methylation Is Widespread at Imprinted Human Loci.G3 (Bethesda, Md.) · 2017Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
Abstract
Imprinted genes are critical for normal human growth and neurodevelopment. They are characterized by differentially methylated regions (DMRs) of DNA that confer parent of origin-specific transcription. We developed a new strategy to identify imprinted gene-associated DMRs. Using genome-wide methylation profiling of sodium bisulfite modified DNA from normal human tissues of biparental origin, candidate DMRs were identified by selecting CpGs with methylation levels consistent with putative allelic differential methylation. In parallel, the methylation profiles of tissues of uniparental origin, i.e., paternally-derived androgenetic complete hydatidiform moles (AnCHMs), and maternally-derived mature cystic ovarian teratoma (MCT), were examined and then used to identify CpGs with parent of origin-specific DNA methylation. With this approach, we found known DMRs associated with imprinted genomic regions as well as new DMRs for known imprinted genes, NAP1L5 and ZNF597, and novel candidate imprinted genes. The paternally methylated DMR for one candidate, AXL, a receptor tyrosine kinase, was also validated in experiments with mouse embryos that demonstrated Axl was expressed preferentially from the maternal allele in a DNA methylation-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.