Evidence map›Paper›PMID 21324834›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2012

Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act.

Stephen S Hecht

Open access · greenAbstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Biomarkers of Tobacco Exposure Decrease After Smokers Switch to an E-Cigarette or Nicotine Gum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Carcinogenic components of tobacco and tobacco smoke: A 2022 update.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Review
  12. Article
  13. Article
  14. Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Article
  15. Article
  16. Identification ofFrontiers in oncology · 2021
    Article
  17. Article
  18. Review
  19. Public Understanding of Cigarette Smoke Chemicals: Longitudinal Study of US Adults and Adolescents.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stephen S HechtMasonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA. hecht002@umn.edu
University of Minnesota · US

Funding

Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI NATALIA Y TRETYAKOVA · 2010 to 2026
$33.4M
METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESR01CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN S HECHT · 1999 to 2026
$7.1M
Metabolism of Carcinogenic Tobacco-Specific NitrosaminesR37CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2004 to 2013
$5.5M
Benzo(a) pyrene Metabolism: Phenotyping and GenotypingR01CA092025 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2001 to 2016
$5.0M
DNA Adducts of the Carcinogen AcetaldehydeR01ES011297 · NIEHS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2002 to 2011
$3.1M
NCI NIH HHS CA-138338NCI NIH HHS CA-81301NCI NIH HHS CA-92025NCI NIH HHS R01 CA081301NCI NIH HHS R01 CA092025NIEHS NIH HHS ES-11297
6 · The paper itself

Abstract

introductionThis paper was written in response to a request from the U.S. National Cancer Institute. The goal is to discuss some research directions related to establishing tobacco product standards under the Family Smoking Prevention and Tobacco Control Act, which empowers the U.S. Food and Drug Administration to regulate tobacco products. Potential research related to tobacco product ingredients, nicotine, and harmful or potentially harmful constituents of tobacco products is discussed. DISCUSSION: Ingredients, which are additives, require less attention than nicotine and harmful or potentially harmful constituents. With respect to nicotine, the threshold level in tobacco products below which dependent users will be able to freely stop using the product if they choose to do so is a very important question. Harmful and potentially harmful constituents include various toxicants and carcinogens. An updated list of 72 carcinogens in cigarette smoke is presented. A crucial question is the appropriate levels of toxicants and carcinogens in tobacco products. The use of carcinogen and toxicant biomarkers to determine these levels is discussed.

conclusionsThe need to establish regulatory standards for added ingredients, nicotine, and other tobacco and tobacco smoke constituents leads to many interesting and potentially highly significant research questions, which urgently need to be addressed.

Indexed as

Government RegulationBiomarkersBiomedical ResearchCarcinogensDrug and Narcotic ControlHumansNicotianaNicotineResearchSmokingSmoking PreventionTobacco IndustryUnited StatesUnited States Food and Drug AdministrationBiomarkersCarcinogensNicotine

Identifiers

PMID21324834
PMCPMC3242967
OpenAlexW2040762771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.