ReviewTrends in pharmacological sciences2011
Impacts of environmental toxicants on male reproductive dysfunction.
Review in Trends in pharmacological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 274 citations in OpenAlex.
- Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: a meta-analysis.Renal failure · 2019Pooled it
- Protective Effects of Mesembryanthemum Crystallinum Extract Against Cadmium-Induced Reproductive Oxidative Stress: Experimental and Docking Evidence for a Sustainable Therapeutic Strategy.Biological trace element research · 2026Article
- Associations of Semen Quality with Essential and Non-Essential Elements in Seminal Fluid.Biological trace element research · 2026Article
- Mucuna pruriens mitigates aging-related testicular dysfunction and sperm parameters by restoring cell adhesion molecules and junctional complexes.Biogerontology · 2026Article
- Investigating the time-dependent withdrawal effects of sofosbuvir and/or ribavirin on male mice: a histological and histophotometrical approach.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Couples exposure to neonicotinoid insecticides and its influence on in vitro fertilization/intracytoplasmic sperm injection outcomes.Environmental health : a global access science source · 2025Article
- Male infertility.Systems biology in reproductive medicine · 2025Review
- Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats.BMC pharmacology & toxicology · 2025Article
- The addition of 5-aminolevulinic acid to HBSS protects testis grafts during hypothermic transportation: a novel preservation strategy.Asian journal of andrology · 2025Article
- Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.Cell death discovery · 2025Review
- Therapeutic roles and molecular mechanisms of Cuscutae Semen in reproductive diseases.Frontiers in immunology · 2025Review
- Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia.Frontiers in endocrinology · 2025Review
- Assessment of reproductive, genotoxic, and cytotoxic effects of leachate-contaminated water in male mice.Heliyon · 2024Article
- Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats.Scientific reports · 2024Article
- Article
- Fabrication strategies for chiral self-assembly surface.Mikrochimica acta · 2024Review
- Effects of Ultraviolet B Radiation on the Function of the Testicles, Expression of Caspase-3 and NOS-2, and the Protective Role of Naringin in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells.Frontiers in pharmacology · 2024Article
- Quantitative Distribution Profile of Cadmium and Lead in Different Organs of Rats and Mitigation of their Accumulation Through Probiotic Treatment.Gut microbes reports · 2024Article
- Redox mechanisms of environmental toxicants on male reproductive function.Frontiers in cell and developmental biology · 2024Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Male infertility caused by exposure to environmental toxicants such as cadmium, mercury, bisphenol A (BPA) and dioxin is a global problem, particularly in industrialized countries. Studies in the testis and other organs have illustrated the importance of environmental toxicant-induced oxidative stress in mediating disruption to cell junctions. This, in turn, is regulated by the activation of PI3K/c-Src/FAK and MAPK signaling pathways, with the involvement of polarity proteins. This leads to reproductive dysfunction such as reduced sperm count and reduced quality of semen. In this review, we discuss how these findings can improve understanding of the modes of action of environmental toxicants in testicular dysfunction. Thus, specific inhibitors and/or antagonists against signaling molecules in these pathways may be able to 'reverse' and/or 'block' the disruptive effects of toxicant-induced damage. Additional studies comparing high-level acute exposure versus low-level chronic exposure to environmental toxicants are also needed to fully elucidate the underlying molecular mechanism(s) by which these toxicants disrupt male reproductive function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.