Evidence map›Paper›PMID 21324503›Full record

ReviewVirology2011

Arenavirus reverse genetics: new approaches for the investigation of arenavirus biology and development of antiviral strategies.

Sebastien E Emonet, Shuzo Urata, Juan C de la Torre

Open access · greenAbstract readReview
In one paragraph

Review in Virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Plasmid-Based Lassa Virus Reverse Genetics.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  16. Review
  17. Review
  18. Membrane dynamics associated with viral infection.Reviews in medical virology · 2016
    Review
  19. Reverse Genetics Approaches to Control Arenavirus.Methods in molecular biology (Clifton, N.J.) · 2016
    Article
  20. Arenavirus Quasispecies and Their Biological Implications.Current topics in microbiology and immunology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sebastien E EmonetDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Shuzo Urata
Juan C de la Torre
Scripps Research Institute · US

Funding

REVERSE GENETICS OF ARENAVIRUSESR01AI047140 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2001 to 2011
$3.0M
Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.R01AI079665 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2009 to 2012
$1.9M
Anti-interferon Activity of the Arenavirus NucleoproteinR01AI077719 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C., MARTINEZ-SOBRIDO, LUIS · 2009 to 2012
$1.6M
NIAID NIH HHS R01 AI047140NIAID NIH HHS R01 AI077719NIAID NIH HHS R01 AI079665
6 · The paper itself

Abstract

Several arenaviruses, chiefly Lassa virus, cause hemorrhagic fever disease in humans and pose a significant public health problem in their endemic regions. On the other hand the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease. The development of novel antiviral strategies to combat pathogenic arenaviruses would be facilitated by a detailed understanding of the arenavirus molecular and cell biology. To this end, the development of reverse genetic systems for several arenaviruses has provided investigators with novel and powerful approaches to dissect the functions of arenavirus proteins and their interactions with host factors required to complete each of the steps of the virus life cycle, as well as to cause disease.

Indexed as

Antiviral AgentsGenetic EngineeringGenetics, MicrobialHost-Pathogen InteractionsHumansLassa virusLymphocytic choriomeningitis virusVirologyVirus ReplicationAntiviral Agents

Identifiers

PMID21324503
PMCPMC3057228
OpenAlexW1997832880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.