ArticleAmerican journal of obstetrics and gynecology2011
Prospective evaluation of insulin resistance among endometrial cancer patients.
Article in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis.BMC cancer · 2018Pooled it
- Serum glucose and risk of cancer: a meta-analysis.BMC cancer · 2014Pooled it
- Measuring the biological effect of presurgical metformin treatment in endometrial cancer.British journal of cancer · 2016Trial
- Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.Reproductive biology and endocrinology : RB&E · 2025Article
- Context-dependent environmental associations with endometrial cancer histotype and genotype.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer.Journal of translational medicine · 2023Review
- Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non-diabetic women.Oncology letters · 2023Article
- Article
- The Effect of Metformin on Expression of Long Non-coding RNA H19 in Endometrial Cancer.Medical journal of the Islamic Republic of Iran · 2021Article
- Identification of a Metabolism-Related Signature for the Prediction of Survival in Endometrial Cancer Patients.Frontiers in oncology · 2021Article
- Review
- Immunotherapy in endometrial cancer: new scenarios on the horizon.Journal of gynecologic oncology · 2019Review
- The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk.International journal of cancer · 2019Article
- Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer,International journal of biological sciences · 2019Article
- The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study.Gynecologic oncology · 2018Article
- Estrogen and high-fat diet induced alterations in C57BL/6 mice endometrial transcriptome profile.Endocrine connections · 2018Article
- Prospective evaluation of abnormal glucose metabolism and insulin resistance in patients with atypical endometrial hyperplasia and endometrial cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study.Gynecologic oncology · 2016Article
- Circulating adiponectin levels and risk of endometrial cancer: Systematic review and meta-analysis.Experimental and therapeutic medicine · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveObesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients. STUDY
designEC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357.
resultsAmong 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index (P < .001), lower socioeconomic status (P = .007), and nulliparity (P = .029).
conclusionIR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.
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