ReviewThe Journal of surgical research2011
Surgical sepsis and organ crosstalk: the role of the kidney.
Review in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Exploring the role of Artificial Intelligence in Acute Kidney Injury management: a comprehensive review and future research agenda.BMC medical informatics and decision making · 2024Pooled it
- Immunometabolic Reprogramming in Experimental Sepsis: A Driver of Multiple Organ Dysfunction Syndrome.Journal of inflammation research · 2026Review
- The Clinical View of Sepsis-Associated AKI: How Basic Science Can Help Solve This Problem.Seminars in nephrology · 2025Review
- Hepato-Renal Crosstalk in Acute and Chronic Disease: From Shared Pathways to Therapeutic Targets.Biomedicines · 2025Review
- Organ crosstalk and dysfunction in sepsis.Annals of intensive care · 2024Review
- Review
- Disruption of Kidney-Immune System Crosstalk in Sepsis with Acute Kidney Injury: Lessons Learned from Animal Models and Their Application to Human Health.International journal of molecular sciences · 2022Review
- Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis.Internal and emergency medicine · 2021Article
- Cardiovascular and Renal Disease in Chronic Critical Illness.Journal of clinical medicine · 2021Review
- Early Prediction for Persistent Inflammation-Immunosuppression Catabolism Syndrome in Surgical Sepsis Patients.International journal of general medicine · 2021Article
- Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.Frontiers in medicine · 2020Review
- Organ crosstalk: the potent roles of inflammation and fibrotic changes in the course of organ interactions.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Article
- Synergistic Effects of Perioperative Complications on 30-Day Mortality Following Hepatopancreatic Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- A zebrafish model of infection-associated acute kidney injury.American journal of physiology. Renal physiology · 2018Article
- Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.Frontiers in immunology · 2018Review
- Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery.Disease markers · 2018Observational
- Inhibition of ALDH2 expression aggravates renal injury in a rat sepsis syndrome model.Experimental and therapeutic medicine · 2017Article
- Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes.The Clinical biochemist. Reviews · 2016Review
- Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction.Surgical infections · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Acute kidney injury (AKI) is a common complication of hospitalized patients, and clinical outcomes remain poor despite advances in renal replacement therapy. The accepted pathophysiology of AKI in the setting of sepsis has evolved from one of simple decreased renal blood flow to one that involves a more complex interaction of intra-glomerular microcirculatory vasodilation combined with the local release of inflammatory mediators and apoptosis. Evidence from preclinical AKI models suggests that crosstalk occurs between kidneys and other organ systems via soluble and cellular inflammatory mediators and that this involves both the innate and adaptive immune systems. These interactions are reflected by genomic changes and abnormal rates of cellular apoptosis in distant organs including the lungs, heart, gut, liver, and central nervous system. The purpose of this article is to review the influence of AKI, particularly sepsis-associated AKI, on inter-organ crosstalk in the context of systemic inflammation and multiple organ failure (MOF).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.