Evidence map›Paper›PMID 21324155›Full record

ReviewReproductive biology and endocrinology : RB&E2011

Milder is better? Advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertilization.

Alberto Revelli, Simona Casano, Francesca Salvagno, Luisa Delle Piane

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02690870 (Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02690870 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF: a Prospective Cohort Study

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2017 to 2019Enrolled210ConditionsInfertilityArmsTamoxifen, Clomiphene
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Surgical or radiological treatment for varicoceles in subfertile men.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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  11. Article
  12. Article
  13. Prevention of Ovarian Hyperstimulation Syndrome: A Review.Obstetrics and gynecology international · 2015
    Review
  14. Article
  15. Article
  16. Should mild stimulation be the order of the day?Journal of human reproductive sciences · 2013
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alberto RevelliReproductive Medicine and IVF Unit, Department of Obstetrical and Gynecological Sciences, University of Torino, via Ventimiglia 3, 10126 Torino, Italy. fertisave@yahoo.com
Simona Casano
Francesca Salvagno
Luisa Delle Piane
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, several steps have been made aiming at rendering human IVF more successful on one side, more tolerable on the other side. The "mild" ovarian stimulation approach, in which a lower-than-average dose of exogenous gonadotropins is given and gonadotropin treatment is started from day 2 to 7 of the cycle, represents a significant step toward a more patient's friendly IVF. However, a clear view of its virtues and defects is still lacking, because only a few prospective randomized trials comparing "mild" vs. conventional stimulation exist, and they do not consider some important aspects, such as, e.g., thawing cycles. This review gives a complete panorama of the "mild" stimulation philosophy, showing its advantages vs. conventional ovarian stimulation, but also discussing its disadvantages. Both patients with a normal ovarian responsiveness to exogenous gonadotropins and women with a poor ovarian reserve are considered. Overall, we conclude that the level of evidence supporting the use of "mild" stimulation protocols is still rather poor, and further, properly powered prospective studies about "mild" treatment regimens are required.

Indexed as

FemaleFertilization in VitroFollicle Stimulating HormoneFollicular PhaseGonadotropin-Releasing HormoneHumansOvarian FollicleOvulation InductionPregnancyPregnancy RateRandomized Controlled Trials as TopicTriptorelin PamoatecetrorelixFollicle Stimulating HormoneGonadotropin-Releasing HormoneTriptorelin Pamoate

Identifiers

PMID21324155
PMCPMC3048523
OpenAlexW2137607076

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.