ArticleBMC neuroscience2011
Structural and functional effects of acoustic exposure in goldfish: evidence for tonotopy in the teleost saccule.
Article in BMC neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 55 citations in OpenAlex.
- The cost of construction noise: A case study on acoustic environment alteration and survival in pupfish (Cyprinodon variegatus).Journal of fish biology · 2026Article
- Zebrafish pou3f3b controls saccular/auditory development and marks non-neuronal cells that delaminate from the otic vesicle to promote neuroblast maturation.Developmental biology · 2026Article
- Vestibular physiology and function in zebrafish.Frontiers in cell and developmental biology · 2023Review
- Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Broad frequency sensitivity and complex neural coding in the larval zebrafish auditory system.Current biology : CB · 2021Article
- Sensorimotor Transformations in the Zebrafish Auditory System.Current biology : CB · 2019Article
- An overview of fish bioacoustics and the impacts of anthropogenic sounds on fishes.Journal of fish biology · 2019Review
- Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Evidence of Cnidarians sensitivity to sound after exposure to low frequency underwater sources.Scientific reports · 2016Article
- Hearing sensitivity differs between zebrafish lines used in auditory research.Hearing research · 2016Article
- Sensory hair cell death and regeneration in fishes.Frontiers in cellular neuroscience · 2015Review
- Identification of a gene set to evaluate the potential effects of loud sounds from seismic surveys on the ears of fishes: a study with Salmo salar.Journal of fish biology · 2014Article
- Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio).PloS one · 2013Article
- Growth hormone promotes hair cell regeneration in the zebrafish (Danio rerio) inner ear following acoustic trauma.PloS one · 2011Article
- Auditory evoked potential audiometry in fish.Reviews in fish biology and fisheriesReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundMammalian and avian auditory hair cells display tonotopic mapping of frequency along the length of the cochlea and basilar papilla. It is not known whether the auditory hair cells of fishes possess a similar tonotopic organization in the saccule, which is thought to be the primary auditory receptor in teleosts. To investigate this question, we determined the location of hair cell damage in the saccules of goldfish (Carassius auratus) following exposure to specific frequencies. Subjects were divided into six groups of six fish each (five treatment groups plus control). The treatment groups were each exposed to one of five tones: 100, 400, 800, 2000, and 4000 Hz at 176 dB re 1 μPa root mean squared (RMS) for 48 hours. The saccules of each fish were dissected and labeled with phalloidin in order to visualize hair cell bundles. The hair cell bundles were counted at 19 specific locations in each saccule to determine the extent and location of hair cell damage. In addition to quantification of anatomical injury, hearing tests (using auditory evoked potentials) were performed on each fish immediately following sound exposure. Threshold shifts were calculated by subtracting control thresholds from post-sound exposure thresholds.
resultsAll sound-exposed fish exhibited significant hair cell and hearing loss following sound exposure. The location of hair cell loss varied along the length of the saccule in a graded manner with the frequency of sound exposure, with lower and higher frequencies damaging the more caudal and rostral regions of the saccule, respectively. Similarly, fish exposed to lower frequency tones exhibited greater threshold shifts at lower frequencies, while high-frequency tone exposure led to hearing loss at higher frequencies. In general, both hair cell and hearing loss declined as a function of increasing frequency of exposure tone, and there was a significant linear relationship between hair cell loss and hearing loss.
conclusionsThe pattern of hair cell loss as a function of exposure tone frequency and saccular rostral-caudal location is similar to the pattern of hearing loss as a function of exposure tone frequency and hearing threshold frequency. This data suggest that the frequency analysis ability of goldfish is at least partially driven by peripheral tonotopy in the saccule.
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