ArticleVeterinary research2011
Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Silent Propagation of Classical Scrapie Prions in Homozygous KEmerging infectious diseases · 2025Article
- Genetic variability of the prion protein gene in Indonesian goat breeds.Tropical animal health and production · 2023Article
- Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPGenetics, selection, evolution : GSE · 2021Article
- Genetic Variation in the Prion Protein Gene (Animals : an open access journal from MDPI · 2021Article
- Novel Polymorphisms and Genetic Characteristics of the Prion Protein Gene (International journal of molecular sciences · 2020Article
- A dominant-negative mutant inhibits multiple prion variants through a common mechanism.PLoS genetics · 2017Article
- Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats.EFSA journal. European Food Safety Authority · 2017Article
- Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.The Journal of general virology · 2017Article
- Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic.Journal of applied genetics · 2017Article
- Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus.Veterinary research · 2016Article
- Goat KVeterinary research · 2016Article
- Article
- Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats.BMC veterinary research · 2016Article
- Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats.Veterinary research · 2014Article
- Role of the goat K222-PrP(C) polymorphic variant in prion infection resistance.Journal of virology · 2014Article
- Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.Veterinary research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In sheep polymorphisms of the prion gene (PRNP) at the codons 136, 154 and 171 strongly influence the susceptibility to scrapie and bovine spongiform encephalopathy (BSE) infections. In goats a number of other gene polymorphisms were found which are suspected to trigger similar effects. However, no strong correlation between polymorphisms and TSE susceptibility in goats has yet been obtained from epidemiological studies and only a low number of experimental challenge data are available at present. We have therefore studied the potential impact of these polymorphisms in vitro by cell-free conversion assays using mouse scrapie strain Me7. Mouse scrapie brain derived PrPSc served as seeds and eleven recombinant single mutation variants of sheep and goat PrPC as conversion targets. With this approach it was possible to assign reduced conversion efficiencies to specific polymorphisms, which are associated to low frequency in scrapie-affected goats or found only in healthy animals. Moreover, we could demonstrate a dominant-negative inhibition of prion polymorphisms associated with high susceptibility by alleles linked to low susceptibility in vitro.
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