Evidence map›Paper›PMID 21323532›Full record

Trial reportAIDS patient care and STDs2011

Randomized controlled trial of a personalized cellular phone reminder system to enhance adherence to antiretroviral therapy.

Helene Hardy, Vikram Kumar, Gheorghe Doros, Eric Farmer, Mari-Lynn Drainoni, Denis Rybin, Dan Myung, Jonathan Jackson, Elke Backman, Anela Stanic and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS patient care and STDs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helene HardyCenter for HIV/AIDS Care and Research, Boston University Medical Center, Massachusetts, USA. hhardy34@gmail.com
Vikram Kumar
Gheorghe Doros
Eric Farmer
Mari-Lynn Drainoni
Denis Rybin
Dan Myung
Jonathan Jackson
Elke Backman
Anela Stanic
Paul R Skolnik

Funding

ARemind: A Personalized System to Remind for Adherence.R43MH080655 · NIMH · DIMAGI, INC. · PI KUMAR, VIKRAM SHEEL · 2007 to 2007
$115k
NIMH NIH HHS 1R43MH080655-01A1
6 · The paper itself

Abstract

Adherence to antiretroviral therapy (ART) represents one of the strongest predictors of progression to AIDS, yet it is difficult for most patients to sustain high levels of adherence. This study compares the efficacy of a personalized cell phone reminder system (ARemind) in enhancing adherence to ART versus a beeper. Twenty-three HIV-infected subjects on ART with self-reported adherence less than 85% were randomized to a cellular phone (CP) or beeper (BP). CP subjects received personalized text messages daily; in contrast, BP subjects received a reminder beep at the time of dosing. Interviews were scheduled at weeks 3 and 6. Adherence to ART was measured by self-report (SR, 7-day recall), pill count (PC, past 30 days at baseline, then past 3 weeks), Medication Event Monitoring System (MEMS; cumulatively at 3 and 6 weeks), and via a composite adherence score constructed by combining MEMS, pill count, and self report. A mixed effects model adjusting for baseline adherence was used to compare adherence rates between the intervention groups at 3 and 6 weeks. Nineteen subjects completed all visits, 10 men and 9 females. The mean age was 42.7 ± 6.5 years, 37% of subjects were Caucasian and 89% acquired HIV heterosexually. The average adherence to ART was 79% by SR and 65% by PC at baseline in both arms; over 6 weeks adherence increased and remained significantly higher in the ARemind group using multiple measures of adherence. A larger and longer prospective study is needed to confirm these findings and to better understand optimal reminder messages and user fatigue.

Indexed as

Cell PhonePatient ComplianceAdultAnti-HIV AgentsFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMaleMiddle AgedPatient ParticipationAnti-HIV Agents

Identifiers

PMID21323532
PMCPMC3101947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.