ArticleMolecular vision2011
Investigation of oxidative stress in pterygium tissue.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- A Randomized Double-Masked Phase 2a Trial to Evaluate Activity and Safety of Topical Ocular Reproxalap, a Novel RASP Inhibitor, in Dry Eye Disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2021Trial
- Randomized Phase 2 Trial of Reproxalap, a Novel Reactive Aldehyde Species Inhibitor, in Patients with Noninfectious Anterior Uveitis: Model for Corticosteroid Replacement.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2020Trial
- Genome-Wide Association Study of Pterygium Versus Pinguecula Identifies Loci Associated with Lesion-Type Divergence.Ophthalmology science · 2026Article
- Oxidative Stress-Induced Age-Related Bullous Keratopathy in Corneal Endothelial Cells With Lipid Droplets and Vacuoles.Investigative ophthalmology & visual science · 2026Article
- Vascular characteristics and haemodynamics of severe and mild pterygium: a quantitative analysis.Annals of medicine · 2025Observational
- Article
- Dynamic thiol disulphide homeostasis in patients with surfer's eye: a case-control study.International ophthalmology · 2022Article
- The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases.International journal of molecular sciences · 2022Review
- Pterygium-The Good, the Bad, and the Ugly.Cells · 2021Review
- Characteristics and recurrence of pterygium in Saudi Arabia: a single center study with a long follow-up.BMC ophthalmology · 2021Article
- Prevalence of Pterygium and Associated Risk Factors in the High-Altitude Area of Ta'if City, Saudi Arabia.Cureus · 2021Article
- Role of oxidative stress and vascular endothelial growth factor expression in pterygium pathogenesis and prevention of pterygium recurrence after surgical excision.International ophthalmology · 2020Article
- Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells.Experimental eye research · 2020Article
- Management of double-head pterygium with conjunctival autograft and primary closure.International medical case reports journal · 2020Article
- Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update.Oxidative medicine and cellular longevity · 2020Review
- A Retrospective Study to Compare the Recurrence Rate After Treatment of Pterygium by Conjunctival Autograft, Primary Closure, and Amniotic Membrane Transplantation.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Essential role of ultraviolet radiation in the decrease of corneal endothelial cell density caused by pterygium.Eye (London, England) · 2018Article
- Pyroptosis in pterygium pathogenesis.Bioscience reports · 2018Article
- The Eye, Oxidative Damage and Polyunsaturated Fatty Acids.Nutrients · 2018Review
- How to minimize pterygium recurrence rates: clinical perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate changes in the oxidant-antioxidant system in pterygium tissue.
methodsTissue samples ablated from 40 patients during pterygium surgery constituted the study material, while normal nasal conjunctiva tissue samples from 20 patients matched for age group (who had undergone surgery for strabismus or extracapsular cataract surgery) were used as controls. The samples were kept at -70 °C until the time of analysis. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) enzymatic activity and the levels of nitric oxide (NO) and malone dialdehyde (MDA) were studied in both groups.
resultsThe mean age was 54.0±12 years in the pterygium patients and 49.0±19 in the controls (p=0.270). The enzyme activity levels were significantly lower in the pterygium group when compared to the controls (p<0.001 in each case), while in the same group a significant increase was observed in the MDA and NO levels (also p<0.001, in both cases).
conclusionsThese findings indicating oxidative stress in the pterygium tissue suggest that oxidative stress can play a role in pterygium etiopathogenesis.
Indexed as
Identifiers
21321673PMC3038211W2141633595What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.