ReviewOncotarget2010
Differential activation of Toll-like receptor-mediated apoptosis induced by hypoxia.
Review in Oncotarget, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Timosaponin AIII mitigates zearalenone-induced kidney injury in weaned piglets in association with TLR/MAPK signaling suppression.Frontiers in veterinary science · 2026Article
- The Protective Effect of Anthocyanins Extracted fromMediators of inflammation · 2021Article
- Immunohistochemical Staining of TLR4 in Human Skeletal Muscle Samples.Bio-protocol · 2019Article
- Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.Bioorganic & medicinal chemistry · 2018Article
- Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism.BMC nephrology · 2018Article
- AT1-receptor blockade: Protective effects of irbesartan in cardiomyocytes under hypoxic stress.PloS one · 2018Article
- TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models.Oncotarget · 2017Article
- Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy.Journal of Korean medical science · 2016Article
- Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders.Molecular neurobiology · 2016Review
- HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK/NF-κB pathway.American journal of translational research · 2016Article
- Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer.Oncotarget · 2015Article
- Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2015Article
- Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation.Scientific reports · 2015Article
- Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4.PloS one · 2015Article
- Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia.Mediators of inflammation · 2015Article
- Standardization of in vitro Cell-based Model for Renal Ischemia and Reperfusion Injury.Indian journal of pharmaceutical sciences · 2014Article
- A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.Cell communication and signaling : CCS · 2014Article
- Apoptosis of bone marrow mesenchymal stem cells caused by hypoxia/reoxygenation via multiple pathways.International journal of clinical and experimental medicine · 2014Article
- Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system.Stem cell research & therapy · 2013Review
- Potential role of Toll-like receptors in programming of vascular dysfunction.Clinical science (London, England : 1979) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemia-reperfusion injury induces intense inflammatory response and tissue damages resulting from the capacity of endogenous constituents called damageassociated molecular patterns (DAMPs) released by damaged or necrotic cells, to activate signaling pathways mediated by receptors of the innate immune systems. Among them, two members of the Toll-like receptors (TLR) family, TLR2 and TLR4 have been shown to play key roles in the induction of inflammatory response and cell apoptosis in a variety of ischemic tissues. The oxidative stress injury caused by I/R injury has been attributed to the activation of MAP kinase pathways, including those of ERK, JNK and p38. Here, we summarise recent findings concerning the role of the protein phosphatase 5 involved in the selective regulation of TLR2-mediated ERK1/2 signaling and the identification of the key role of the non-phagocytic NADPH oxidase 4 producing reactive oxygen species in the control of TLR4-mediated apoptosis in murine models of renal I/R injury and in post-hypoxic kidney tubule cells. The identification of molecules signaling involved in the ER stress-induced apoptotic signaling cascade may therefore represent potential targets to prevent the induction of apoptosis in hypoxic tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.