ArticleThe Journal of biological chemistry2011
Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium Sorangium cellulosum So ce56.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Ornithine lipids and other acyloxyacyl amino lipids: the coming-of-age story of a group of non-canonical membrane lipids.Applied microbiology and biotechnology · 2026Review
- Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Genes required for phosphosphingolipid formation in Caulobacter crescentus contribute to bacterial virulence.PLoS pathogens · 2024Article
- Lipopolysaccharide ofInternational journal of molecular sciences · 2023Article
- Intact polar lipidome and membrane adaptations of microbial communities inhabiting serpentinite-hosted fluids.Frontiers in microbiology · 2023Article
- The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons.The Science of the total environment · 2021Article
- The Fluidity of the Bacterial Outer Membrane Is Species Specific: Bacterial Lifestyles and the Emergence of a Fluid Outer Membrane.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- Direct visualization of a molecular handshake that governs kin recognition and tissue formation in myxobacteria.Nature communications · 2019Article
- Article
- Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei.Journal of lipid research · 2017Article
- Host-Associated Genomic Features of the Novel Uncultured Intracellular Pathogen Ca. Ichthyocystis Revealed by Direct Sequencing of Epitheliocysts.Genome biology and evolution · 2016Article
- Neutral and Phospholipids of the Myxococcus xanthus Lipodome during Fruiting Body Formation and Germination.Applied and environmental microbiology · 2015Article
- A comprehensive insight into the lipid composition of Myxococcus xanthus by UPLC-ESI-MS.Journal of lipid research · 2014Article
- Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.PloS one · 2014Article
- Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor.BMC microbiology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gram-negative myxobacterium Sorangium cellulosum So ce56 bears the largest bacterial genome published so far, coding for nearly 10,000 genes. Careful analysis of this genome data revealed that part of the genes coding for the very well conserved biosynthesis of lipopolysaccharides (LPS) are missing in this microbe. Biochemical analysis gave no evidence for the presence of LPS in the membranes of So ce56. By analyzing the lipid composition of its outer membrane sphingolipids were identified as the major lipid class, together with ornithine-containing lipids (OL) and ether lipids. A detailed analysis of these lipids resulted in the identification of more than 50 structural variants within these three classes, which possessed several interesting properties regarding to LPS replacement, mediators in myxobacterial differentiation, as well as potential bioactive properties. The sphingolipids with the basic structure C9-methyl-C(20)-sphingosine possessed as an unusual trait C9-methylation, which is common to fungi but highly uncommon to bacteria. Such sphingolipids have not been found in bacteria before, and they may have a function in myxobacterial development. The OL, also identified in myxobacteria for the first time, contained acyloxyacyl groups, which are also characteristic for LPS and might replace those in certain functions. Finally, the ether lipids may serve as biomarkers in myxobacterial development.
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