ArticleThe Journal of infectious diseases2011
Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Advances in vaccine development for Chlamydia trachomatis.Pathogens and disease · 2024Review
- Cohousing with Dirty Mice Increases the Frequency of Memory T Cells and Has Variable Effects on Intracellular Bacterial Infection.ImmunoHorizons · 2022Article
- Article
- Article
- Shift work influences the outcomes of Chlamydia infection and pathogenesis.Scientific reports · 2020Article
- Parenteral vaccination protects against transcervical infection withNPJ vaccines · 2020Article
- Article
- Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.Frontiers in cellular and infection microbiology · 2019Article
- RepeatedEpidemiology and infection · 2018Article
- Diversity in the T cell response to Chlamydia-sum are better than one.Immunology letters · 2018Review
- Immunization with Chlamydia psittaci plasmid-encoded protein CPSIT_p7 induces partial protective immunity against chlamydia lung infection in mice.Immunologic research · 2018Article
- Chlamydia muridarum Genital and Gastrointestinal Infection Tropism Is Mediated by Distinct Chromosomal Factors.Infection and immunity · 2018Article
- Infection of Hysterectomized Mice with Chlamydia muridarum and Chlamydia trachomatis.Infection and immunity · 2017Article
- Comparison of Murine Cervicovaginal Infection by Chlamydial Strains: Identification of Extrusions ShedFrontiers in cellular and infection microbiology · 2017Article
- Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile.Clinical and vaccine immunology : CVI · 2015Article
- CD8+ T cells mediate Chlamydia pneumoniae-induced atherosclerosis in mice.Pathogens and disease · 2015Article
- A vaccine formulated with a combination of TLR-2 and TLR-9 adjuvants and the recombinant major outer membrane protein elicits a robust immune response and significant protection against a Chlamydia muridarum challenge.Microbes and infection · 2014Article
- The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword.Frontiers in immunology · 2014Review
- A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice.Vaccine · 2013Article
- Animal models for studying female genital tract infection with Chlamydia trachomatis.Infection and immunity · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chlamydia muridarum and Chlamydia trachomatis mouse models of genital infection have been used to study chlamydial immunity and vaccine development. To assess the protective role of CD4(+) T cells in resolving C. trachomatis and C. muridarum genital tract infections, we used the female mouse model and evaluated infection in the presence and absence of CD4(+) T cells. In contrast to C. muridarum infection, C. trachomatis infection was unaltered in the absence of CD4(+) T cells. Mice infected with C. trachomatis developed protective immunity to re-challenge, but unlike C. muridarum infection, optimum resistance required multiple infectious challenges, despite the generation of adaptive serum and local chlamydial specific immune responses. Thus, understanding the chlamydial pathogenic and host immunologic factors that result in a diminished protective role for CD4(+) T cells in C. trachomatis murine infection might lead to new insights important to human immunity and vaccine development.
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Registered trials
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