ArticleInfection and immunity2011
Reductionistic and holistic science.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From Microbial Dynamics to Functionality in the Rhizosphere: A Systematic Review of the Opportunities With Synthetic Microbial Communities.Frontiers in plant science · 2021Pooled it
- Conquering today's health paradox with the power of HEAL - an expert consensus report plus research priorities and policymaker roadmap.Frontiers in public health · 2026Article
- Ubuntu as a blueprint: learning ethical transdisciplinarity from African indigenous knowledge systems.Frontiers in research metrics and analytics · 2026Article
- Editorial: Perspectives in molecular viral pathogenesis.Frontiers in cellular and infection microbiology · 2026Article
- Toxin-antitoxins and sigma factors may optimize the fitness of free-living bacteria throughout the life cycle via an integrated nutrient-responsive cybernetic system.Journal of the Royal Society, Interface · 2025Review
- Organ-Specific Small Protein Networks in 100 kDa Ultrafiltrates: Functional Analysis and Implications for Neuroregenerative Medicine.International journal of molecular sciences · 2025Article
- The Oral Microbiome: A Key Determinant of Oral Health.Advances in experimental medicine and biology · 2025Review
- Toward a roadmap for addressing today's health dilemma-The 101-statement consensus report.Frontiers in nutrition · 2025Article
- Review
- Editorial: What is up with psychedelics anyway?Frontiers in neuroscience · 2023Article
- Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis.Frontiers in microbiology · 2022Review
- What is One Health?The Canadian veterinary journal = La revue veterinaire canadienne · 2021Article
- Adaptive Capacities and Complexity of Heart Rate Variability in Patients With Chronic Obstructive Pulmonary Disease Throughout Pulmonary Rehabilitation.Frontiers in physiology · 2021Article
- Multitissue Multiomics Systems Biology to Dissect Complex Diseases.Trends in molecular medicine · 2020Review
- Framing the Intractable: Comprehensive Success Factor Analysis for Grand Challenges.Sustainable futures (Amsterdam, Netherlands) · 2020Article
- Infrastructures of systems biology that facilitate functional genomic study in rice.Rice (New York, N.Y.) · 2019Review
- Elegant Science.mBio · 2018Article
- Systems toxicology meta-analysis ofToxicology research · 2017Article
- 47 Years of IAI: a Glance in the Mirror and the Road Ahead.Infection and immunity · 2017Article
- From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering.Advances in experimental medicine and biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A reductionistic approach to science, epitomized by molecular biology, is often contrasted with the holistic approach of systems biology. However, molecular biology and systems biology are actually interdependent and complementary ways in which to study and make sense of complex phenomena.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.