ArticleInfection and immunity2011
Impact of salmonella infection on host hormone metabolism revealed by metabolomics.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 72 citations in OpenAlex.
- Eugenol nanoemulsion protects chickens against S. Typhimurium infection by improving cecal barrier function and alleviating oxidative stress and inflammation.Poultry science · 2026Article
- Metabolomic profiling of host-pathogen interactions: differential effects of Gram-positive and Gram-negative bacterial secretomes on THP-1 macrophage metabolism.RSC advances · 2025Article
- Cecal Metabolome Profiles of Turkey Poults in Response toAnimals : an open access journal from MDPI · 2025Article
- Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes.Scientific reports · 2023Article
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- Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense.PLoS pathogens · 2021Article
- Roles of Eicosanoids in Regulating Inflammation and Neutrophil Migration as an Innate Host Response to Bacterial Infections.Infection and immunity · 2021Article
- Global metabolomic analysis of blood from mice infected with Brucella abortus.The Journal of veterinary medical science · 2021Article
- Responses of testosterone hormone and important inflammatory cytokines in bucks after challenge with Mannheimia haemolytica A2 and its LPS endotoxin.Tropical animal health and production · 2021Article
- Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected WithFrontiers in immunology · 2021Article
- Review
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- Unified feature association networks through integration of transcriptomic and proteomic data.PLoS computational biology · 2019Article
- Organic Acids Modulate Systemic Metabolic Perturbation Caused byFrontiers in physiology · 2019Article
- The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon.Frontiers in microbiology · 2019Article
- Article
- Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity.Molecular and cellular biochemistry · 2018Article
- PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected WithFrontiers in microbiology · 2018Article
- Hepatic Metabolomics Investigation in Acute and Chronic Murine Toxoplasmosis.Frontiers in cellular and infection microbiology · 2018Article
- Repression of Salmonella Host Cell Invasion by Aromatic Small Molecules from the Human Fecal Metabolome.Applied and environmental microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The interplay between pathogens and their hosts has been studied for decades using targeted approaches, such as the analysis of mutants and host immunological responses. Although much has been learned from such studies, they focus on individual pathways and fail to reveal the global effects of infection on the host. To alleviate this issue, high-throughput methods, such as transcriptomics and proteomics, have been used to study host-pathogen interactions. Recently, metabolomics was established as a new method to study changes in the biochemical composition of host tissues. We report a metabolomic study of Salmonella enterica serovar Typhimurium infection. Our results revealed that dozens of host metabolic pathways are affected by Salmonella in a murine infection model. In particular, multiple host hormone pathways are disrupted. Our results identify unappreciated effects of infection on host metabolism and shed light on mechanisms used by Salmonella to cause disease and by the host to counter infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.