ArticleInfection and immunity2011
Induction of experimental endocarditis by continuous low-grade bacteremia mimicking spontaneous bacteremia in humans.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Antibiotics in Mucogingival Surgery for Recession Treatment: A Narrative Review.Antibiotics (Basel, Switzerland) · 2025Review
- Acquired ventricular septal defect secondary to aortic valve endocarditis.Journal of cardiothoracic surgery · 2025Article
- Transient bacteremia following the removal of four different types of rapid palatal expanders.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024Article
- Cardiac Implantable Electronic Devices Infection Assessment, Diagnosis and Management: A Review of the Literature.Journal of clinical medicine · 2022Review
- Dynamics of a Staphylococcus aureus infective endocarditis simulation model.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies.Frontiers in cell and developmental biology · 2022Review
- Review
- Review
- Isolating Crucial Steps in Induction of Infective Endocarditis With Preclinical Modeling of Host Pathogen Interaction.Frontiers in microbiology · 2020Article
- Article
- Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis.mSphere · 2019Article
- Infective endocarditis: innovations in the management of an old disease.Nature reviews. Cardiology · 2019Review
- Article
- Aspirin Effect onFrontiers in medicine · 2019Review
- Dental procedures, antibiotic prophylaxis, and endocarditis among people with prosthetic heart valves: nationwide population based cohort and a case crossover study.BMJ (Clinical research ed.) · 2017Article
- Oral Streptococcal Endocarditis, Oral Hygiene Habits, and Recent Dental Procedures: A Case-Control Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Antibodies Targeting Hsa and PadA Prevent Platelet Aggregation and Protect Rats against Experimental Endocarditis Induced by Streptococcus gordonii.Infection and immunity · 2016Article
- Elevated levels of circulating DNA in cardiovascular disease patients: metagenomic profiling of microbiome in the circulation.PloS one · 2014Article
- From in vitro to in vivo Models of Bacterial Biofilm-Related Infections.Pathogens (Basel, Switzerland) · 2013Review
- Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis.Infection and immunity · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient high-grade bacteremia following invasive procedures carries a risk of infective endocarditis (IE). This is supported by experimental endocarditis. On the other hand, case-control studies showed that IE could be caused by cumulative exposure to low-grade bacteremia occurring during daily activities. However, no experimental demonstration of this latter possibility exists. This study investigated the infectivity in animals of continuous low-grade bacteremia compared to that of brief high-grade bacteremia. Rats with aortic vegetations were inoculated with Streptococcus intermedius, Streptococcus gordonii or Staphylococcus aureus (strains Newman and P8). Animals were challenged with 10(3) to 10(6) CFU. Identical bacterial numbers were given by bolus (1 ml in 1 min) or continuous infusion (0.0017 ml/min over 10 h). Bacteremia was 50 to 1,000 times greater after bolus than during continuous inoculation. Streptococcal bolus inoculation of 10(5) CFU infected 63 to 100% vegetations compared to 30 to 71% infection after continuous infusion (P > 0.05). When increasing the inoculum to 10(6) CFU, bolus inoculation infected 100% vegetations and continuous infusion 70 to 100% (P > 0.05). S. aureus bolus injection of 10(3) CFU infected 46 to 57% valves. This was similar to the 53 to 57% infection rates produced by continuous infusion (P > 0.05). Inoculation of 10(4) CFU of S. aureus infected 80 to 100% vegetations after bolus and 60 to 75% after continuous infusion (P > 0.05). These results show that high-level bacteremia is not required to induce experimental endocarditis and support the hypothesis that cumulative exposure to low-grade bacteremia represents a genuine risk of IE in humans.
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