Evidence map›Paper›PMID 21321035›Full record

ReviewPediatrics2011

Health effects of energy drinks on children, adolescents, and young adults.

Sara M Seifert, Judith L Schaechter, Eugene R Hershorin, Steven E Lipshultz

Erratum issued Registry-linked trialAbstract readReview
In one paragraph

Review in Pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03021616 (Evaluation of Energy Drink Consumption on Electrocardiographic, Vascular and Hematologic Parameters in Young Healthy Volunteers), which is not on this map. Cited by 280 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03021616 naterminatednot on this mapstarted 2017, after this paper: background citation

Evaluation of Energy Drink Consumption on Electrocardiographic, Vascular and Hematologic Parameters in Young Healthy Volunteers: A Randomized, Double Blind, Active-Controlled, Crossover Study

TypeinterventionalSponsorDavid Grant U.S. Air Force Medical CenterRan2017 to 2018Enrolled2ConditionsCardiovascular DiseasesArmsenergy drink, Moxifloxacin 400mg, Placebo
3 · Its place in the literature

Who cites it

280 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Caffeine Consumption in Children: Innocuous or Deleterious? A Systematic Review.International journal of environmental research and public health · 2020
    Pooled it
  2. Pooled it
  3. Trial
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  8. Acute effects of energy drinks in medical students.European journal of nutrition · 2017
    Trial
  9. Article
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  11. Review
  12. Review
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  15. Review
  16. Article
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  18. Observational
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220 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sara M SeifertDepartment of Pediatrics and Pediatric Integrative Medicine Program, University of Miami, Leonard M. Miller School of Medicine, Miami, Florida 33101, USA.
Judith L Schaechter
Eugene R Hershorin
Steven E Lipshultz

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Zebrafish Screens for Genetic Modifiers and Human Application in T-ALLP01CA068484 · NCI · DANA-FARBER CANCER INSTITUTE · PI SILVERMAN, LEWIS B · 1995 to 2010
$31.9M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
PEDIATRIC CARDIOMYOPATHY REGISTRYR01HL053392 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1995 to 2009
$8.3M
Cardiovascular Status of HAART-Exposed Infants/ChildrenR01HL072705 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 2002 to 2006
$5.6M
TRAINING PROGRAMS IN CARDIOVASCULAR PHARMACOLOGYT32HL007188 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SZCZESNA-CORDARY, DANUTA · 1985 to 2011
$3.8M
Women and Infants Transmission Study IVU01AI050274 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICH, KENNETH C · 2001 to 2005
$3.6M
Pediatric Cardiomyopathy Specimen RepositoryR01HL087000 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TOWBIN, JEFFREY ALLEN · 2007 to 2010
$2.2M
HAART Associated Cardiotoxicity in HIV-Infected ChildrenR01HL078522 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIPSHULTZ, STEVEN EDWARD · 2004 to 2008
$2.0M
Atherosclerotic Risk and Response to Exercise Intervention in HIV+ ChildrenR01HL095127 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MILLER, TRACIE L · 2008 to 2010
$1.1M
FELLOWSHIP IN CLINICAL RESEARCHK30HL004537 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SCOTT, GWENDOLYN BARBARA · 2000 to 2004
$1.0M
Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer SurvivorsR01CA127642 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIPSHULTZ, STEVEN EDWARD · 2007 to 2009
$997k
NCI NIH HHS CA068484NCI NIH HHS CA127642NCI NIH HHS P01 CA068484NCI NIH HHS R01 CA127642NHLBI NIH HHS F31 HL094100NHLBI NIH HHS HL004537NHLBI NIH HHS HL007188NHLBI NIH HHS HL053392NHLBI NIH HHS HL072705NHLBI NIH HHS HL078522NHLBI NIH HHS HL079233NHLBI NIH HHS HL087000NHLBI NIH HHS HL087708NHLBI NIH HHS HL094100NHLBI NIH HHS HL095127NHLBI NIH HHS K30 HL004537NHLBI NIH HHS R01 HL053392NHLBI NIH HHS R01 HL072705NHLBI NIH HHS R01 HL078522NHLBI NIH HHS R01 HL087000NHLBI NIH HHS R01 HL095127NHLBI NIH HHS R13 HL087708NHLBI NIH HHS T32 HL007188NIAID NIH HHS AI50274NIAID NIH HHS U01 AI050274NICHD NIH HHS HD052102NICHD NIH HHS HD052104NICHD NIH HHS HD80002NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104PHS HHS HCOF-C76HF15614
6 · The paper itself

Abstract

objectiveTo review the effects, adverse consequences, and extent of energy drink consumption among children, adolescents, and young adults.

methodsWe searched PubMed and Google using "energy drink," "sports drink," "guarana," "caffeine," "taurine," "ADHD," "diabetes," "children," "adolescents," "insulin," "eating disorders," and "poison control center" to identify articles related to energy drinks. Manufacturer Web sites were reviewed for product information.

resultsAccording to self-report surveys, energy drinks are consumed by 30% to 50% of adolescents and young adults. Frequently containing high and unregulated amounts of caffeine, these drinks have been reported in association with serious adverse effects, especially in children, adolescents, and young adults with seizures, diabetes, cardiac abnormalities, or mood and behavioral disorders or those who take certain medications. Of the 5448 US caffeine overdoses reported in 2007, 46% occurred in those younger than 19 years. Several countries and states have debated or restricted energy drink sales and advertising.

conclusionsEnergy drinks have no therapeutic benefit, and many ingredients are understudied and not regulated. The known and unknown pharmacology of agents included in such drinks, combined with reports of toxicity, raises concern for potentially serious adverse effects in association with energy drink use. In the short-term, pediatricians need to be aware of the possible effects of energy drinks in vulnerable populations and screen for consumption to educate families. Long-term research should aim to understand the effects in at-risk populations. Toxicity surveillance should be improved, and regulations of energy drink sales and consumption should be based on appropriate research.

Indexed as

DrinkingFeeding BehaviorHealth BehaviorAdolescentAdolescent BehaviorCentral Nervous System StimulantsChildChild BehaviorHumansYoung AdultCentral Nervous System Stimulants

Identifiers

PMID21321035
PMCPMC3065144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.