ArticleNeuroscience2011
Multiple origins of cholinergic innervation of the cochlear nucleus.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Cholinergic modulation in the vertebrate auditory pathway.Frontiers in cellular neuroscience · 2024Review
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- Olivocochlear projections contribute to superior intensity coding in cochlear nucleus small cells.The Journal of physiology · 2022Article
- Enzymes of acetylcholine metabolism in the rat inferior colliculus.Brain research · 2021Article
- Effects of brainstem lesions on amino acid levels in the rat cochlear nucleus.Hearing research · 2021Article
- Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multiple Sources of Cholinergic Input to the Superior Olivary Complex.Frontiers in neural circuits · 2021Article
- Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus.eLife · 2020Article
- Amino acid and acetylcholine chemistry in mountain beaver cochlear nucleus and comparisons to pocket gopher, other rodents, and cat.Hearing research · 2020Article
- Chemical Effects of Kainic Acid Injection into the Rat Superior Olivary Region.HSOA journal of otolaryngology, head & neck surgery · 2020Article
- Article
- Quantitative distribution of choline acetyltransferase activity in rat trapezoid body.Hearing research · 2018Article
- Stereological Estimates of Glutamatergic, GABAergic, and Cholinergic Neurons in the Pedunculopontine and Laterodorsal Tegmental Nuclei in the Rat.Frontiers in neuroanatomy · 2018Article
- Muscarinic acetylcholine receptors control baseline activity and Hebbian stimulus timing-dependent plasticity in fusiform cells of the dorsal cochlear nucleus.Journal of neurophysiology · 2017Article
- Radiate and Planar Multipolar Neurons of the Mouse Anteroventral Cochlear Nucleus: Intrinsic Excitability and Characterization of their Auditory Nerve Input.Frontiers in neural circuits · 2017Article
- Modulating central gain in tinnitus: changes in nitric oxide synthase in the ventral cochlear nucleus.Frontiers in neurology · 2015Article
- Increased contralateral suppression of otoacoustic emissions indicates a hyperresponsive medial olivocochlear system in humans with tinnitus and hyperacusis.Journal of neurophysiology · 2014Article
- The ascending mesolimbic cholinergic system--a specific division of the reticular activating system involved in the initiation of negative emotional states.Journal of molecular neuroscience : MN · 2014Review
- Cholinergic modulation of large-conductance calcium-activated potassium channels regulates synaptic strength and spine calcium in cartwheel cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cochlear damage affects neurotransmitter chemistry in the central auditory system.Frontiers in neurology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Acetylcholine (Ach) affects a variety of cell types in the cochlear nucleus (CN) and is likely to play a role in numerous functions. Previous work in rats suggested that the acetylcholine arises from cells in the superior olivary complex, including cells that have axonal branches that innervate both the CN and the cochlea (i.e. olivocochlear cells) as well as cells that innervate only the CN. We combined retrograde tracing with immunohistochemistry for choline acetyltransferase to identify the source of ACh in the CN of guinea pigs. The results confirm a projection from cholinergic cells in the superior olivary complex to the CN. In addition, we identified a substantial number of cholinergic cells in the pedunculopontine tegmental nucleus (PPT) and the laterodorsal tegmental nucleus (LDT) that project to the CN. On average, the PPT and LDT together contained about 26% of the cholinergic cells that project to CN, whereas the superior olivary complex contained about 74%. A small number of additional cholinergic cells were located in other areas, including the parabrachial nuclei.The results highlight a substantial cholinergic projection from the pontomesencephalic tegmentum (PPT and LDT) in addition to a larger projection from the superior olivary complex. These different sources of cholinergic projections to the CN are likely to serve different functions. Projections from the superior olivary complex are likely to serve a feedback role, and may be closely tied to olivocochlear functions. Projections from the pontomesencephalic tegmentum may play a role in such things as arousal and sensory gating. Projections from each of these areas, and perhaps even the smaller sources of cholinergic inputs, may be important in conditions such as tinnitus as well as in normal acoustic processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.